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Latest DNA replication Stories

2011-06-17 03:00:00

BLUE BELL, Pa., June 17, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO) announced today that its subsidiary VGX Animal Health, Inc., a developer of DNA-based vaccines and therapies for companion and food animals, has achieved strong T cell responses from VAH-5000D, its DNA vaccine encoding telomerase reverse transcriptase (TERT) for the treatment of dogs with cancer. This preclinical data was presented by Dr. Douglas Kern, DVM, VGX Animal Health's Vice President of...

2011-05-23 14:22:03

A rare genetic disease called dyskeratosis congenita, caused by the rapid shortening of telomeres (protective caps on the ends of chromosomes), can be mimicked through the study of undifferentiated induced pluripotent stem cells, according to new findings from the Stanford University School of Medicine. Although dyskeratosis affects only about one in a million people, the scientists' findings could greatly facilitate research into this and other diseases caused by stem cell malfunctions,...

2011-05-06 14:25:04

Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth. Their latest findings, published today in Molecular Cell, demonstrate that telomerase repairs chromosomes in one of two ways "“ depending on whether a cell is dividing normally or if the cell is under stress from enzyme inhibition "“ and could lead to new or improved cancer-fighting therapies that promote inhibition...

2011-05-03 14:52:43

Damage to normal DNA is a hallmark of cancer cells. Although it had previously been known that damage to normal cells is caused by stress to their DNA replication when cancerous cells invade, the molecular basis for this remained unclear. Now, for the first time, researchers at the Hebrew University of Jerusalem have shown that in early cancer development, cells suffer from insufficient building blocks to support normal DNA replication. It is possible to halt this by externally supplying the...

2011-04-16 00:41:30

A Berkeley Lab-led team deciphers the structure of FEN1, a key player in DNA replication and repair DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role. The structure of human FEN1 has now been solved by an international team of scientists led by the...

2011-03-23 20:36:01

New findings link telomerase activation to chromosome instability and tumor development in several common cancers It's been nearly 10 years since Beth Israel Deaconess Medical Center (BIDMC) scientists Kun Ping Lu, MD, PhD and Xiao Zhen Zhou, MD, discovered PinX1, the first potent endogenous protein shown to inhibit telomerase in mammals. Now the scientific team has discovered a vitally important new function for this telomerase inhibitor. The investigators report in today's on-line edition...

2011-03-03 23:27:38

Discovery of molecular mechanism reveals antitumor possibilities Researchers at the Johns Hopkins School of Medicine have discovered that a natural product isolated from a traditional Chinese medicinal plant commonly known as thunder god vine, or lei gong teng, and used for hundreds of years to treat many conditions including rheumatoid arthritis works by blocking gene control machinery in the cell. The report, published as a cover story of the March issue of Nature Chemical Biology, suggests...

2011-03-03 12:38:13

A novel study from Karolinska Institutet has deepened the understanding of how chromosome replication, one of life's most fundamental processes, works. In a long term perspective these results could eventually lead to novel cancer therapies. The study is presented in the prestigious scientific journal Nature. By studying DNA replication in yeast cells, researchers at Karolinska Institutet have discovered that a protein complex (Smc5/6) helps to release torsional stress created in the DNA...

2011-02-14 15:13:00

IPSWICH, Mass., Feb. 14, 2011 /PRNewswire/ -- New England Biolabs has expanded its line of PCR reagents to include OneTaq(TM) and OneTaq Hot Start DNA Polymerases. Optimized blends of Taq and Deep Vent(®) DNA Polymerases, these new products offer robust amplification across a wide range of templates, including routine, AT-rich and GC-rich amplicons. The 3´-5´ exonuclease activity of Deep Vent increases the fidelity and robustness of...

2011-01-18 22:07:10

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases. The enzyme, known as Rad18, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair. When Pol eta is not present, alternative error-prone polymerases take...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.