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Latest DNA replication Stories

2011-01-18 22:07:10

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases. The enzyme, known as Rad18, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair. When Pol eta is not present, alternative error-prone polymerases take...

2011-01-13 11:04:00

NEW YORK, Jan. 13, 2011 /PRNewswire/ -- Telomerase Activation Sciences, Inc. (T.A. Sciences) today announced the issuance of U.S. Patent No. 7,846,904 to the Geron Corporation. The patent covers the use of certain compounds to upregulate telomerase expression in cells. T.A. Sciences has exclusive worldwide rights to technology under this patent for nutraceutical and cosmetic applications. "This foundational patent is a validation of the millions of dollars and more than 8 years of...

2010-11-30 16:32:00

RENO, Nev., Nov. 30, 2010 /PRNewswire/ -- On Sunday, a team of scientists at Harvard Medical School led by Dr. Ronald DePinho published research providing strong scientific support for the validity of Sierra Sciences' approach to curing aging. Their research demonstrated for the first time that turning on telomerase and lengthening telomeres will reverse the symptoms of old age in a living animal. These findings appear as a research article entitled 'Telomerase reactivation reverses...

2010-11-15 21:42:10

Biologists at the University of California, San Diego have found another member in a new class of cellular motor proteins that rewind and seal together sections of the double-stranded DNA molecule that occasionally but perilously become unwound. Their discovery, which provides a promising new avenue for the development of drugs that kill cancer cells, is detailed in a paper published in this week's early online edition of the Proceedings of the National Academy of Sciences. The same...

2010-11-04 17:40:20

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die. But in some cells, such as cancer cells, telomerase,...

2010-10-08 02:15:08

Accurate duplication of genetic material and the faithful segregation of chromosomes are critical for cell survival. The initiation of DNA replication is linked both to cell cycle progression and chromatin organization. In plants, animals and other "eukaryotes," the assembly of a multi-protein complex called pre-replicative complex (preRC) is the first step in the initiation of DNA replication. As the name implies, origin recognition complex (ORC) proteins bind to origins of DNA replication....

2010-09-16 17:54:55

Not only do undergraduate students gain valuable hands-on experience by participating in scientific research projects, but they also make meaningful contributions, examples of which are highlighted in the current special issue of DNA and Cell Biology, a peer-reviewed journal published by Mary Ann Liebert, Inc. The issue is available free online. This special issue features a collection of papers reporting on successful research projects in which undergraduate students played a significant...

2010-09-02 06:50:00

PALM SPRINGS, Calif., Sept. 2 /PRNewswire/ -- Scientists at Elan Vital Pharmaceuticals announce anti-aging technology applications to a new product, De-Nouveau. De-Nouveau utilizes the Nobel Prize-winning discovery of the enzyme telomerase to change the anti-aging product market. Telomerase allows cellular DNA to recombine the same way a young person's DNA does. De-Nouveau by Elan Vital re-introduces the telomerase enzyme into the body to dramatically slow down the signs of aging....

2010-07-02 20:12:59

Tufts biologists' findings have potential to advance development of new cancer drugs Tufts University researchers in the School of Arts and Sciences have pinpointed a key cellular protein that repairs damaged DNA molecules but may also promote the development of cancer. Assistant Professor of Biology Mitch McVey and his research team report that DNA polymerase theta, or PolQ, promotes an inaccurate repair process, which can ultimately cause mutations, cell death or cancer. The research is...

2010-06-22 07:00:00

SAN DIEGO, June 22 /PRNewswire/ -- The National Institutes of Health recently awarded TriLink BioTechnologies, Inc. (TriLink) a Phase II SBIR Grant of approximately $725,000 to continue their work on developing reagents to enhance the specificity of DNA ligase. In these continued studies, the utility of chemically modified components will be explored as a potential means of enhancing ligation fidelity in a variety of advanced applications that employ DNA ligase, including SNP detection,...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.