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Latest DNA replication Stories

2010-01-07 14:29:49

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered how a protein long known to be an essential activator of DNA replication actually triggers this process in cells. The protein, called DDK (for Ddf4-dependent protein kinase), is an enzyme that attaches phosphate molecules to other proteins to modify their activity. The CSHL team has found that DDK performs this operation, called phosphorylation, on a protein called Mcm4, specifically within a domain that acts as a built-in...

2010-01-04 07:55:17

An experimental drug currently being tested against breast and lung cancer shows promise in fighting the brain cancer glioblastoma and prostate cancer, researchers at UT Southwestern Medical Center have found in two preclinical studies. The drug's actions, observed in isolated human cells in one trial and in rodents in the other, are especially encouraging because they attacked not only the bulk of the tumor cells but also the rare cancer stem cells that are believed to be responsible for...

2009-12-10 12:56:50

MIT and Boston University researchers have discovered that the drug hydroxyurea kills bacteria by inducing them to produce molecules toxic to themselves "” a conclusion that raises the possibility of finding new antibiotics that use similar mechanisms. Hydroxyurea inhibits the enzyme critical for making the building blocks for DNA, so for decades it has been used to study the consequences of inhibiting DNA replication in E. coli, yeast and mammalian cells. It is also sometimes used in...

2009-12-03 14:00:00

Research could lead to an understanding of how accurate DNA replication occurs to prevent mutations known to result in cancer and genetic diseases DETROIT, Dec. 3 /PRNewswire-USNewswire/ -- Wayne State researchers have for the first time observed the movement of a single molecule of DNA polymerase as it incorporates nucleotides one by one. More significantly, they have identified a previously unknown step that they speculate is part of the proofreading process known to prevent the...

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2009-11-24 12:23:36

The atomic-level action of a remarkable class of ring-shaped protein motors has been uncovered by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) using a state-of-the-art protein crystallography beamline at the Advanced Light Source (ALS). These protein motors play pivotal roles in gene expression and replication, and are vital to the survival of all biological cells, as well as infectious agents, such as the human papillomavirus, which has been linked to cervical...

2009-10-27 14:13:26

Scientists here have identified how the motions of an enzyme are related to correctly copying genetic instructions, setting the stage for studies that can uncover what happens when DNA copying mistakes are made. Perpetuation of DNA mistakes can cause mutations that lead to cancer and other diseases. But before scientists can determine how and when errors are made during DNA replication, they must first fully understand what's going on when the copying process works properly "“ a...

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2009-10-21 11:47:59

Researchers report that a single-stranded DNA-binding protein (SSB), once thought to be a static player among the many molecules that interact with DNA, actually moves back and forth along single-stranded DNA, gradually allowing other proteins to repair, recombine or replicate the strands. Their study, of SSB in the bacterium Escherichia coli, appears today in the journal Nature. Whenever the double helix of DNA unravels, exposing each strand to the harsh environment of the cell, SSB is...

2009-10-15 14:02:21

By discovering the atomic structure of a key human enzyme, researchers at The University of Texas at Austin have pointed the way toward designing anti-HIV drugs with far less toxic side effects. Their work was published this week in Cell. "Many anti-HIV drugs are designed to stop the process of DNA replication," says Dr. Whitney Yin, assistant professor of chemistry and biochemistry. "That turns out to be a great thing to do to help cure virus infections, because it stops the processes of...

2009-10-07 09:42:27

Using computer simulations, a team of University of Wisconsin-Madison researchers has identified some of the pathways through which single complementary strands of DNA interact and combine to form the double helix. Present in the cells of all living organisms, DNA is composed of two intertwined strands and contains the genetic "blueprint" through which all living organisms develop and function. Individual strands consist of nucleotides, which include a base, a sugar and a phosphate moiety....

2009-10-05 08:43:00

SAN FRANCISCO, Oct. 5 /PRNewswire-USNewswire/ -- Molecular biologist Elizabeth H. Blackburn, PhD, 60, of the University of California, San Francisco, today was named to receive the 2009 Nobel Prize in Physiology or Medicine. Blackburn shares the award with Carol W. Greider of Johns Hopkins University School of Medicine and Jack W. Szostak of Harvard Medical School. The scientists discovered an enzyme that plays a key role in normal cell function, as well as in cell aging and most...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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