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Latest Downregulation and upregulation Stories

Sleep Deprivation Elderly Blood Sugar
2013-12-12 08:42:00

redOrbit Staff & Wire Reports - Your Universe Online Normal aging may exacerbate the negative effect of sleep deprivation on pancreatic cells that maintain normal blood sugar levels, according to a study published this month in the journal Aging Cell. Sleep, or the lack of it, seems to affect nearly every aspect of human physiology, although the molecular pathways through which sleep deprivation wreaks havoc on the body remain poorly understood. Numerous studies have looked at the...

2012-01-09 17:25:30

New research published in the American Journal of Pathology New research reveals that insulin applied in therapeutic doses selectively stimulates the formation of new elastic fibers in cultures of human aortic smooth muscle cells. These results advance the understanding of the molecular and cellular mechanisms of diabetic vascular disease. The study is published in the February issue of the American Journal of Pathology. "Our results particularly endorse the use of insulin therapy for...

2011-05-16 14:37:57

Gene expression reprogramming may allow cancer cell growth as well as normal differentiation Gene expression is the process of converting the genetic information encoded in DNA into a final gene product such as a protein or any of several types of RNA. Scientists have long thought that the gene programs regulated by different physiological processes throughout the body are robustly pre-determined and relatively fixed for every specialized cell. But a new study by researchers from the...

2010-03-29 07:36:53

Novel approach may circumvent lost response in insulin due to obesity Researchers at Children's Hospital Boston have identified a new strategy for treating type 2 diabetes, identifying a cellular pathway that fails when people become obese. By activating this pathway artificially, they were able to normalize blood glucose levels in severely obese and diabetic mice. Their findings were published online by Nature Medicine on March 28. Epidemiologists have long known that obesity contributes to...

2005-08-11 19:20:00

BOSTON - Using the newest DNA chip technology, scientists at Joslin Diabetes Center have discovered a new gene implicated in the cause of type 2 diabetes. In a new study appearing in the August 12 issue of the journal Cell, the investigators first identified genes that were altered in their level of expression in islets isolated from people with type 2 diabetes. The researchers then went on to show that when they created a defect in one of these genes called ARNT in mice, the mice developed...

2005-07-20 16:20:00

BOSTON -- A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein found in fat cells is a newly discovered cause of insulin resistance, establishing a previously unidentified molecular link between obesity and type 2 diabetes and offering a potential new target for the development of drugs to treat diabetes. The findings appear in the July 21, 2005, issue of the journal Nature. According to senior author Barbara B. Kahn, MD, Chief of the Division of...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'