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Latest Dynorphin Stories

Scientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
2014-01-13 07:13:26

Scripps Research Institute The findings pave way for new therapies for treating pain and mood disorders Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery, from The Scripps Research Institute (TSRI) and the University of North Carolina (UNC), suggests new therapeutic approaches to a host of brain-related medical conditions. "It opens the door to understanding opioid related...

2013-06-13 09:58:47

Scientists at The Scripps Research Institute (TSRI) have found evidence that an emotion-related brain region called the central amygdala–whose activity promotes feelings of malaise and unhappiness–plays a major role in sustaining cocaine addiction. In experiments with rats, the TSRI researchers found signs that cocaine-induced changes in this brain system contribute to anxiety-like behavior and other unpleasant symptoms of drug withdrawal–symptoms that typically drive an...

2012-07-06 10:25:40

Researchers decode a molecular mechanism that sheds light on how trauma can become engraved in the brain Feelings of anxiety very effectively prevent people from getting into situations that are too dangerous. Those who have had a terrible experience initially tend to avoid the place of tragedy out of fear. If no other oppressive situation arises, normally the symptoms of fear gradually subside. "The memory of the terrible events is not just erased." states first author, PD Dr. Andras...

2012-06-27 00:56:05

Prenatal exposure to the environmental contaminants polychlorinated biphenyls, or PCBs, causes long-term changes to the developing brain that have adverse effects on reproductive function later in life, a new study finds. Results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston. The study used rats, whose genes and molecules in the hypothalamus–the region of the brain important for reproductive function–are virtually identical to those in...

2009-10-30 17:21:08

Effect is on pathways that regulate serotonin and can lead to low mood Stress-evoked changes in circuits that regulate serotonin in certain parts of the brain can precipitate a low mood and a relapse in cocaine-seeking, based on mouse studies published online this week in the Proceedings of the National Academy of Sciences. "The impetus for this research was our interest in how stress alters the brain's cell receptors and protein signals in ways that lead to mood changes, depression, anxiety,...

2009-03-20 11:01:39

A study of rodents confirmed that low-to-moderate levels of alcohol alter beta-endorphins producing a general feeling of well-being, Canadian researchers said. Corresponding author Christina Gianoulakis of McGill University in Montreal said alcohol may increase or decrease the release and the synthesis of endogenous opioid peptides -- endorphins released during excitement, pain and orgasm -- in distinct brain regions important for drug addiction. Some of the functions of opioid peptides are...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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