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Latest Dyskeratosis congenita Stories

2012-03-26 11:03:13

Few molecules are more interesting than DNA–except of course RNA. After two decades of research, that "other macromolecule" is no longer considered a mere messenger between glamorous DNA and protein-synthesizing machines. We now know that RNA has been leading a secret life, regulating gene expression and partnering with proteins to form catalytic ribonucleoprotein (RNP) complexes. One of those RNPs is telomerase, an enzyme that maintains chromosome integrity. In the March 25, 2012,...

2012-03-21 21:37:37

Worm model of back-up telomere repair strategy could speed identification of anti-cancer drugs Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome. Loss of telomeres forces cells out of the dividing game and into a growth arrest state called "senescence," but cancer cells evade this by employing an enzyme called telomerase to extend eroded...

2011-07-29 13:03:11

Telomeres, the complex structures that protect the end of chromosomes, of peripheral blood cells are significantly shorter in patients with familial breast cancer than in the general population. Results of the study carried out by the Human Genetics Group of the Spanish National Cancer Research Centre (CNIO), led by Javier Benitez, to be published in open-access journal PLoS Genetics on July 28th, reflect that familial, but not sporadic, breast cancer cases are characterized by shorter...

2011-06-08 08:00:00

NEW YORK, June 8, 2011 /PRNewswire/ -- When expressed (turned on), the gene (hTERT) located on Chromosome number 5p15.33 activates the enzyme telomerase. Human cells can keep living and dividing indefinitely when telomerase is continually present; i.e. the cells become immortal. Telomerase Activation Sciences, Inc. (T.A. Sciences®) announces TA-65® can extend human cell life indefinitely. TA-65® is a single molecule telomerase activator...

2011-05-23 14:22:03

A rare genetic disease called dyskeratosis congenita, caused by the rapid shortening of telomeres (protective caps on the ends of chromosomes), can be mimicked through the study of undifferentiated induced pluripotent stem cells, according to new findings from the Stanford University School of Medicine. Although dyskeratosis affects only about one in a million people, the scientists' findings could greatly facilitate research into this and other diseases caused by stem cell malfunctions,...

2011-04-12 10:48:00

MALAGA, Spain, April 12, 2011 /PRNewswire/ -- Groundbreaking research touting the benefits of telomerase activation has been published in Aging Cell, the # 1 journal in geriatrics and gerontology. (Photo: http://photos.prnewswire.com/prnh/20100908/NY60832-a) (Logo: http://photos.prnewswire.com/prnh/20100908/NY60832LOGO-b ) The study, "The Telomerase Activator TA-65 elongates short telomeres and increases healthspan of adult/old mice without increasing cancer incidence" describes...

2011-03-24 18:01:44

New role for short telomeres New evidence has emerged from studies in mice that short telomeres or "caps" at the ends of chromosomes may predispose people to age-related diabetes, according to Johns Hopkins scientists. Telomeres are repetitive sequences of DNA that protect the ends of chromosomes, and they normally shorten with age, much like the caps that protect the end of shoelaces. As telomeres shorten, cells lose the ability to divide normally and eventually die. Telomere shortening has...

2011-03-23 20:36:01

New findings link telomerase activation to chromosome instability and tumor development in several common cancers It's been nearly 10 years since Beth Israel Deaconess Medical Center (BIDMC) scientists Kun Ping Lu, MD, PhD and Xiao Zhen Zhou, MD, discovered PinX1, the first potent endogenous protein shown to inhibit telomerase in mammals. Now the scientific team has discovered a vitally important new function for this telomerase inhibitor. The investigators report in today's on-line edition...

2010-11-30 16:32:00

RENO, Nev., Nov. 30, 2010 /PRNewswire/ -- On Sunday, a team of scientists at Harvard Medical School led by Dr. Ronald DePinho published research providing strong scientific support for the validity of Sierra Sciences' approach to curing aging. Their research demonstrated for the first time that turning on telomerase and lengthening telomeres will reverse the symptoms of old age in a living animal. These findings appear as a research article entitled 'Telomerase reactivation reverses...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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