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Latest Dystroglycan Stories

2012-01-09 19:10:35

Study reveals function of glycosylating enzyme involved in muscular dystrophy, brain development and infection by arenaviruses such as Lassa fever; ability to assay enzyme activity could help screen potential muscular dystrophy therapies Researchers at the University of Iowa have worked out the exact function of an enzyme that is critical for normal muscle structure and is involved in several muscular dystrophies. The findings, which were published Jan. 6 in the journal Science, could be...

2011-03-16 08:17:01

(Ivanhoe Newswire) "“ University of Iowa researchers have identified a new gene mutation that causes muscular dystrophy. In addition, by engineering the human gene mutation into a mouse, the researchers, have created a new mouse model that could help screen potential drugs to treat this type of muscular dystrophy. Normal dystroglycan, a protein that is abnormal in a group of congenital muscular dystrophies, is extensively modified with added sugar chains. This modification allows...

2011-03-10 13:33:28

Mutation in important muscle protein causes muscle disease and cognitive impairment A strong international collaboration and a single patient with mild muscle disease and severe cognitive impairment have allowed University of Iowa researchers to identify a new gene mutation that causes muscular dystrophy. Furthermore, by engineering the human gene mutation into a mouse, the researchers, led by Kevin Campbell, Ph.D., professor and head of molecular physiology and biophysics at the UI Carver...

2010-01-01 10:37:46

With the discovery of a new type of chemical modification on an important muscle protein, a University of Iowa study improves understanding of certain muscular dystrophies and could potentially lead to new treatments for the conditions. The findings, which appear in the Jan. 1, 2010, issue of the journal Science, may also have implications for detecting metastasizing cancer cells. After they are initially made, most proteins are modified through the addition of sugar chains, fats or other...

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2009-07-23 14:00:00

A new study by scientists at the University of Iowa shows why muscle membranes don't rupture when healthy people exercise.The findings shed light on a mechanism that appears to protect cells from mechanical stress. The study, which appears online July 20-24 in Proceedings of the National Academy of Sciences (PNAS) Early Edition, also helps explain why muscle damage is so severe when this mechanism is disrupted, which occurs in certain congenital and limb-girdle muscular...

2009-01-14 06:18:27

A protein that was first identified for playing a key role in regulating normal heart rhythms also appears to be significant in helping muscle cells survive the forces of muscle contraction. The clue was a laboratory mouse that seemed to have a form of muscular dystrophy. A group of proteins called ankyrins, or anchor proteins, were first discovered in human red blood cells by Vann Bennett, M.D. a Howard Hughes Medical Institute investigator and James B. Duke Professor of Cell Biology,...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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