Latest E2F Stories

2012-08-29 07:06:26

8-9 percent of human diabetes is type 3c; Olatz Zenarruzabeitia, a biologist at the University of the Basque Country, is analysing a pathway for developing it as well as preventing it in mice Mice develop pancreatic diabetes (type 3c) when they lack certain genes in the E2F group, and to understand how this happens, Olatz Zenarruzabeitia has focussed on the molecular mechanism behind it. This researcher works at the laboratory of Ana Zubiaga, Professor of Genetics of the University of the...

2012-04-16 22:24:14

    The E2F family of genes is thought to play a crucial role in regulating cell proliferation.     It is unclear how these genes carry out their function and interact with one another in intact animals.     This study shows that two E2F repressor genes are essential for a functional placenta and for balancing the effect of an E2F activator gene. Two particular repressor genes in a family of regulatory genes are vital for controlling cell...

2011-12-13 22:57:01

Chemical disruption to key interaction shown to limit metastasis in test mice Finding ways to counteract or disrupt the invasive nature of cancer cells, called "metastasis," has been a long-term goal of cancer researchers. Now, researchers at Moffitt Cancer Center in Tampa, Fla., have identified an interactive pathway that regulates metastases in some cancers that may be vulnerable to chemical targeting in order to prevent cancer cell proliferation and tumor growth. Ongoing...

2011-10-31 11:23:58

Understanding the endocycle has implications for agriculture and medicine An international team of researchers led by investigators in the U.S. and Germany has shed light on the inner workings of the endocycle, a common cell cycle that fuels growth in plants, animals and some human tissues and is responsible for generating up to half of the Earth's biomass. This discovery, led by a geneticist at Fred Hutchinson Cancer Research Center and reported Oct. 30 in Nature, leads to a new...

2010-01-04 10:06:02

The master regulator of muscle differentiation, MyoD, functions early in myogenesis to help stem cells proliferate in response to muscle injury, according to researchers at Case Western Reserve University. The study appears online Jan. 4 in the Journal of Cell Biology. MyoD is a transcription factor that activates muscle-specific genes as myoblast precursors differentiate and fuse to form mature muscle fibers. But MyoD is also expressed at an earlier stage of myogenesis when quiescent stem...

2008-03-24 10:15:00

Investigators at the Duke Institute for Genome Sciences and Policy have revealed the hidden properties of an on-off switch that governs cell growth. The Duke team proved that if the switch is on, then a cell will divide, even if it's damaged or the signal to grow disappears. Showing how the switch works may provide clues to novel drug targets for cancer and other diseases in which cell growth goes awry.The switch is part of a critical pathway that controls cell division, the process by which...

Word of the Day
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.