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Latest Efflux Stories

2014-01-27 23:02:49

Research led by St. Jude Children’s Research Hospital scientists has produced new versions of an old antibiotic that are active against difficult-to-treat tuberculosis; offers new strategy for overcoming drug resistance Memphis, TN (PRWEB) January 27, 2014 St. Jude Children’s Research Hospital scientists have discovered a promising new class of antibiotics that could aid efforts to overcome drug-resistance in tuberculosis (TB), a global killer. The drugs increased survival of mice...

2012-03-28 17:42:06

ABC transporters are membrane proteins that actively pump a wealth of molecules across the membrane. Over 40 different ABC transporters perform vital functions in humans. Genetic defects in ABC transporters can trigger metabolic diseases such as gout, neonatal diabetes or cystic fibrosis, and certain ABC transporters also cause resistance to a wide range of drugs. In tumor cells, increased amounts of ABC transporters that pump chemotherapeutic substances out of the cell are often produced,...

2012-02-20 20:28:32

Aggressive infections in hospitals are an increasing health problem worldwide. The development of bacterial resistance is alarming. Now a young Danish scientist has found a natural substance in a Chilean rainforest plant that effectively supports the effect of traditional treatment with antibiotics. PhD Jes Gitz Holler from the University of Copenhagen discovered in a research project a compound that targets a particular resistance mechanism in yellow staphylococci. The development of...

2011-12-09 11:52:42

Food prices are soaring at the same time as the Earth's population is nearing 9 billion. As a result the need for increased crop yields is extremely important. New research led by Carnegie's Wolf Frommer into the system by which sugars are moved throughout a plant -- from the leaves to the harvested portions and elsewhere -- could be crucial for addressing this problem. Their work is published Dec. 8 by Science Express. Just as it's necessary for the human body to move nutrients to all of...

2011-11-28 23:11:01

Chemists at Brown University have synthesized a new compound that makes drug-resistant bacteria susceptible again to antibiotics. The compound – BU-005 – blocks pumps that a bacterium employs to expel an antibacterial agent called chloramphenicol. The team used a new and highly efficient method for the synthesis of BU-005 and other C-capped dipeptides. Results appear in Bioorganic and Medicinal Chemistry. It´s no wonder that medicine´s effort to combat bacterial...

2011-11-03 03:50:00

Unique Technology Enables Early Prediction of Drug-Drug Interactions Involving Transporters Exton, PA (PRWEB) November 02, 2011 Absorption Systems, a leader in testing drugs for ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity), today announced that patents have issued in Europe (no. 2084529) and Panama (no. 87554-01) covering its novel Breast Cancer Resistance Protein (BCRP) knockdown cell line within the companyâs CellPort Technologies® brand. These...

2011-05-11 23:43:28

Advanced biofuels "“ liquid transportation fuels derived from the cellulosic biomass of perennial grasses and other non-food plants, as well as from agricultural waste "“ are highly touted as potential replacements for gasoline, diesel and jet fuels. Equally touted is the synthesis of these fuels through the use of microbes. However, many of the best candidate compounds for advanced biofuels are toxic to microbes, which presents a "production versus survival" conundrum....

2011-03-03 23:12:18

Inexpensive drugs already approved for other uses can block tolerance mechanism New findings on how tuberculosis (TB) bacteria develop multi-drug tolerance point to ways TB infections might be cured more quickly. The study will be published April 1 in the journal Cell. The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect. Currently, TB treatment requires a complex, long-term curative regimen of at...

2011-02-23 17:42:44

A research team led by Edward Yu of Iowa State University and the Ames Laboratory has identified and described two parts of the three-part system that pumps toxins from bacteria and allows them to resist antibiotics. The discoveries are published in the Feb. 24 issue of the journal Nature. The paper describes the co-crystal structure of two parts of the three-part efflux pump that recognizes and removes heavy metal toxins from bacteria. A research team led by Yu "“ an Iowa State...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.