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Latest Endoplasmic reticulum Stories

2011-08-24 21:47:27

Trafficking pathway for hundreds of cell proteins reconstructed and tested The delivery system for an important class of proteins in the cell membrane can be fully replicated with a mere three components, according to a new study. Tail-anchored proteins, the molecular machines that make up approximately five percent of the membrane proteins in a cell, are known to have their own special pathway for trafficking to the membrane after construction. New research from the University of...

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2011-04-23 10:50:00

Research in the worm is shedding light on a protein associated with a number of different human cancers, and may point to a highly targeted way to treat them.University of Wisconsin-Madison scientists were studying a worm protein called TFG-1, which is present in many cell types but whose exact role had never been understood. The scientists discovered that the protein controls key aspects of the movement, or secretion, of growth factors out of cells."TFG-1 has never been implicated in the...

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2010-07-28 09:05:13

Defining of novel mechanism informs understanding of cancer, aging physiology University of Pennsylvania School of Medicine  researchers have described a previously unknown biological mechanism in cells that prevents them from cannibalizing themselves for fuel. The mechanism involves the fuel used by cells under normal conditions and relies on an ongoing transfer of calcium between two cell components via an ion channel. Without this transfer, cells start consuming themselves as a way of...

2010-05-10 07:44:28

The new findings may inspire clinical trials In findings that advance scientists' understanding of a whole class of inherited disorders, a team from The Scripps Research Institute has shed light on a mechanism that enables a potential treatment for Gaucher's disease and other lysosomal storage diseases. The findings were published in an advance, online edition of the journal Nature Chemical Biology on May 9, 2010. "This study is likely to motivate clinical trials for the treatment of...

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2009-07-29 13:20:00

'Atlastin' builds critical structures; does job in fundamentally new way Italian and U.S. biologists this week report that a little-understood protein previously implicated in a rare genetic disorder plays an unexpected and critical role in building and maintaining healthy cells. Even more surprising, their report in the journal Nature shows that the protein, called "atlastin," does its work by fusing intracellular membranes in a previously undocumented way."If you'd asked me a year ago...

2009-05-06 16:22:31

U.S. researchers say they have evidence to explain what separates average blood vessel plaque from those that trigger blood clots. The study, published in the journal Cell Metabolism, suggest drugs designed to tackle a form of cellular stress might be useful in treating heart disease. Just about everybody in our society has atherosclerosis by the time we reach 20, Ira Tabas of Columbia University in New York said in a statement. The billion-dollar question is why 98 percent cause no...

2008-08-28 18:00:19

Researchers at Temple University in Philadelphia said that fat in obese patients is "sick" when compared to fat in lean patients. Lead author Dr. Guenther Boden theorizes that "sick fat" could more fully explain the link between obesity and higher risk of diabetes, heart disease and stroke. Researchers from the departments of endocrinology, biochemistry and surgery at the Temple University School of Medicine took fat biopsies from the upper thighs of six lean and six obese patients and...

2008-03-19 15:35:00

Researchers at the University of Pennsylvania School of Medicine have provided, for the first time, a detailed look at the molecular pathways underlying sleep apnea, which affects more than twelve million Americans, according to the National Institutes of Health. Sleep apnea is a condition characterized by temporary breathing interruptions during sleep, in which disruptions can occur dozens or even hundreds of times a night. The team found that in an animal model of sleep apnea poorly folded...


Word of the Day
penuche
  • A fudgelike confection of brown sugar, cream or milk, and chopped nuts.
'Penuche' is a variant of 'panocha,' a coarse grade of sugar made in Mexico. 'Panocha' probably comes from the Spanish 'panoja, panocha,' ear of grain.
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