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Latest Endosome Stories

2013-08-21 10:17:14

A new hypothesis concerning a crucial step in the anthrax infection process has been advanced by scientists at the National Institute of Standards and Technology (NIST) and the U.S. Army Medical Research Institute for Infectious Diseases (USAMRIID) at Fort Detrick, Md. The research teams have explored the behavior of the toxins that rapidly overwhelm the body as the often-fatal disease progresses. Their findings suggest a new possible mechanism by which anthrax bacteria deliver the protein...

Scientists Create Temporary Holes In Cells
2013-01-23 19:20:00

Lee Rannals for redOrbit.com — Your Universe Online [ Watch the Video: Delivering Large Molecules to Cells In Membranes ] Researchers from the Massachusetts Institute of Technology (MIT) have found a safe way to squeeze large molecules through a narrow construction in cell membranes. The membrane around living cells helps to regulate what gets in and out of the cell. This barrier helps control the cell´s internal environment, but makes it difficult for scientists to...

2012-04-02 09:27:32

IFITM3 protein is critical to the structure and function of cellular machinery involved in blocking virus production Scientists from the University of Utah School of Medicine have discovered that a mouse protein called IFITM3 contributes to the body's defense against some types of viral infections by binding to an enzyme responsible for regulating the pH of a cell's waste disposal system. This finding, published in the March 30, 2012, issue of Innate Immunity, sheds light on the cellular...

2010-06-15 15:42:37

The degradation of proteins and other macromolecules in cells is vital to survival. Disruption of this process can result in serious disease. The research group of Professor Thomas Jentsch (Leibniz Institute for Molecular Pharmacology, FMP/ Max Delbrck Center for Molecular Medicine, MDC, Berlin-Buch) has now succeeded in identifying an essential cellular process necessary for the transport and degradation of macromolecules in endosomes and lysosomes, respectively. In two studies published in...

2010-06-15 15:21:26

Scientists from the University of Leeds have discovered the mechanisms of a protein known to play an active part in the inherited kidney disorder, Dent's disease. The findings provide a new focus for future therapies for the disease, for which there is currently no cure. Dent's disease is an extremely rare illness caused by a genetic mutation on the X chromosome. Affecting mostly men, its main symptom is kidney stones often followed by a deterioration of kidney function and in many cases...

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2010-03-05 10:31:37

Max Planck scientists develop new strategy to play major role in research on human diseases Cells may not have a mouth, but they still need to ingest substances from the external environment. If this process - known as endocytosis - is affected, it can lead to infectious diseases or cardio-vascular diseases, cancer, Huntington's and diabetes. In cooperation with the Center for Information Services and High Performance Computing (ZIH) at the Dresden University of Technology, scientists from...

2010-01-04 15:34:28

Inheritance of an extra copy of the gene- ÃŽ² -amyloid precursor protein, APP, in individuals with Down syndrome leads to the inevitable development of early onset Alzheimer's disease, known to be linked to the deposition of Amyloid ÃŽ² peptide or AÃŽ² in the brain. However, a new study published online by Proceedings of the National Academy of Sciences identifies ÃŽ²CTF, a small protein found in APP, as a novel factor for...

2009-05-01 08:47:31

Scientists may need to rethink the design of drugs meant to block HIV from infecting human cells, according to a study that appears in the May 1st issue of the journal Cell, a Cell Press publication. That's because the new report shows that HIV doesn't enter cells in the way that experts had generally assumed it did.Rather than fusing directly with the plasma membrane at cells' outer surfaces to release its contents, HIV fusion primarily occurs via smaller, membrane-bound compartments inside...