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Last updated on April 19, 2014 at 13:20 EDT

Latest Enzymes Stories

Unraveling Mysteries Of Amyloid Beta Peptides To Detect And Treat Alzheimer's Disease
2014-02-18 07:41:38

American Institute of Physics Alzheimer's disease has long been marked by progress -- but not the kind of progress the medical community seeks. It is the most common form of dementia among older Americans, and its risk increases with increasing age; for those living with the disease, its ravages get worse over time; and as we move into the 21st century, it will place a greater and greater burden on society. The number of Americans living with Alzheimer's has doubled since 1980 and is...

2014-02-10 12:26:14

GOSSELIES, Belgium, February 10, 2014 /PRNewswire/ -- iTeos Therapeutics SA today announced the filing of the Company's first patent applications protecting proprietary inhibitors of the intracellular enzyme TDO2, which is expressed at high levels in specific cancers. iTeos Therapeutics has collaborated with Ludwig Cancer Research over the last year to identify small molecule inhibitors of the enzyme that display nanomolar potency, good selectivity, favorable pharmacokinetics...

2014-02-06 23:23:00

New research on carbonic anhydrase confirms its value as a treatment target, with limitations. Raleigh, NC (PRWEB) February 06, 2014 New research published in a European medical journal and reported by Surviving Mesothelioma suggests that a cell surface enzyme may provide a new target for mesothelioma therapy. Carbonic anhydrases are a large family of enzymes responsible for a range of biological processes. Carbonic anhydrase IX (CAIX) is a specific carbonic anhydrase involved in...

2014-01-13 10:21:10

New Study Pinpoints Structural Effects of V44M and V44A Mutations New research, led by Rensselaer Polytechnic Institute researcher Chunyu Wang, has solved one mystery in the development of Familial Alzheimer’s Disease (FAD), a genetic variant of the disease that affects a small fraction of the Alzheimer’s population. In a paper published January 6 in the journal Nature Communications, Wang and his team follow the trail of two genetic mutations – V44M and V44A – known to cause FAD,...

2014-01-07 23:02:06

Two new publications by a team from Western University of Health Sciences shed further light on the mechanisms of learning and memory, and neuronal degeneration. Pomona, California (PRWEB) January 07, 2014 Two new publications by a team from Western University of Health Sciences shed further light on the mechanisms of learning and memory, and neuronal degeneration. The first paper, “A molecular brake controls the magnitude of long-term potentiation,” by Yubin Wang, Guoqi Zhu, Victor...

2014-01-06 10:17:40

Earlier amyloid-beta assemblies may be one of the most important causes of Alzheimer's disease. Passive immunization of anti-amyloid-beta antibodies can reduce amyloid-beta burden and improved memory performance in various Alzheimer's disease animal models or patients. Screening humanized antibodies from a human Fab phage display library is an effective and quick method to obtain beta-amyloid oligomers. Thus, a recent study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013)...

2013-12-16 12:00:42

Findings may be useful in design of future drugs and catalysts The theory of evolution suggests that present-day organisms evolved from earlier life forms. At the molecular level, evolution reshaped some of the enzymes that help complete chemical processes—such as converting food into energy—in humans and all other life forms. Now a University of Iowa researcher and his colleagues describe the evolution of various forms of the enzyme “dihydrofolate reductase” as it occurred...

2013-12-11 12:09:51

New study adds to existing resource that identifies targets for SIRT3 The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation. In a new study published in the Dec. 3rd 2013 issue of Cell Metabolism, Buck Institute researchers have now identified widespread regulation of proteins involved in metabolism by the mitochondrial sirtuin, SIRT5.  Using a novel quantitative proteomic...

2013-12-09 10:00:24

PKM2 controls mitosis, saving cancer cells from death and promoting brain tumor growth Researchers have caught a protein they previously implicated in a variety of cancer-promoting roles performing a vital function in cell division, survival and development of brain tumors. In a paper published in Molecular Cell, Zhimin Lu, Ph.D., professor of Neuro-Oncology at The University of Texas MD Anderson Cancer Center and colleagues report how a tumor-specific protein flips a crucial switch in...

How Genomes Are Copied
2013-12-03 09:30:50

Umea University For the first time, researchers at Umeå University have succeeded in showing how the DNA polymerase epsilon enzyme builds new genomes. The detailed image produced by these researchers shows how mutations that can contribute to the development of colorectal cancer and cervical cancer lead to changes in the structure of the protein. This study will be published in the journal Nature Structural and Molecular Biology. Genomes are built from pairs of long strands of DNA. In...