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Latest Epidermal growth factor receptor Stories

2013-06-03 10:54:17

A subset of colorectal cancers responds to anti-epidermal growth factor receptor (anti-EGFR) therapies, but develops resistance within months. Among cancers that develop resistance to anti-EGFR therapy, some showed overexpression of a gene called MET, according to a study published in the June issue of Cancer Discovery, a journal of the American Association for Cancer Research. Preliminary data published in this study showed human tumors with MET amplification, grown in mice, responded to MET...

2013-05-08 11:39:52

A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues to overcome drug resistance, according to researchers at Duke Cancer Institute. "We've revealed multiple new signaling pathways that regulate cell death," said Sally Kornbluth, PhD, vice dean of Basic Science and professor of Pharmacology and Cancer Biology at Duke...

2013-04-22 14:18:26

Union with Shc keeps potential troublemaker away from bad company and out of the nucleus A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology. Shc, pronounced "schick," plays a key role in activating signals which lead to cell proliferation (and cancer)...

Reshaping Chemo Drugs Helps Them Target And Attack Cancer Cells
2013-02-28 11:10:10

Watch the video "Chemotherapy Drugs Getting Better at Targeting Cancer Cells" redOrbit Staff & Wire Reports - Your Universe Online Changing the shape of chemotherapy drug nanoparticles to make them rod-shaped rather than spherical can enhance their effectiveness in targeting and treating breast cancer cells by as much as 10,000-fold, according to new research from bioengineers at the University of California, Santa Barbara (UCSB). As part of the research, a team led by Samir...

Targeting Cancer With New Microscopy Technique
2013-02-26 12:58:30

University of Akron For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been impossible, until now. Thanks to a new microscopy technique, University of Akron researcher Dr. Adam Smith, assistant professor of chemistry, has observed how clusters of epidermal growth factor receptor (EGFR) – a protein abundant in lung and colon cancers, glioblastoma and others – malfunctions in...

2013-02-07 15:25:23

A new approach mimicking the body's natural defenses could help treat a therapy-resistant breast cancer Cancer drugs of the new, molecular generation destroy malignant breast tumors in a targeted manner: They block characteristic molecules on tumor cells - receptors for the hormones estrogen or progesterone, or a co-receptor, called HER2, that binds to many growth factors. But about one in every six breast tumors has none of these receptors. Such cancers, called triple-negative, are...

A Traffic Cop For Stopping Cancer Cells?
2013-01-15 05:53:23

Connie K. Ho for redOrbit.com — Your Universe Online Researchers from the Fox Chase Cancer Center recently discovered a novel method of improving cancer drugs, where they could block a specific pathway in the cell and provide an easier way for drugs to eliminate tumors. According to the American Cancer Society, cancer occurs when there is uncontrolled growth and expansion of abnormal cells. It is caused by external factors (such as chemicals, infectious organisms, radiation, and...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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