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Latest Epidermal growth factor receptor Stories

2012-02-02 18:00:09

Breakthroughs demonstrate importance of targeted therapies Different kinds of lung cancer behave in different ways, suggesting they are fundamentally different diseases. According to a University of Colorado Cancer Center study published in Cancer, the official journal of the American Cancer Society, different subgroups of non-small cell lung cancer (NSCLC) show distinct patterns of spread in the body. The study looked at 209 patients diagnosed with stage IV non-small cell lung cancer...

2012-01-23 10:44:09

The work will be published in the latest issue of Nature Medicine journal Doctors and researchers of Hospital del Mar and its research institute, the IMIM, have lead a study describing a new pharmacological resistance to cancer. This new mechanism is a mutation in an oncogene called EGFR (epidermal growth factor receptor) causing resistance to treatment using a drug called cetuximab, a monoclonal antibody which specifically attacks the EGFR. The study proves that, both in lab models and...

2012-01-19 15:06:30

    The most common form of lung cancer inevitably develops resistance to the targeted drug gefitinib.     This study shows how this resistance develops.     The findings suggest a new strategy for treating non-small cell lung cancer. New research published in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain...

2011-12-12 22:17:53

Scientists have pinpointed a protein that allows brains tumors to invade healthy brain tissue, according to work published this week in the Journal of Experimental Medicine (http://www.jem.org). 40% of a common but deadly type of brain tumor -- called glioblastoma multiforme (GBM) -- have mutations in a gene that encodes a protein called epidermal growth factor receptor (EGFR). These mutations result in hyper-activation of the protein. A team led by Frank Furnari of the Ludwig Institute...

2011-11-14 15:24:49

Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, may have the potential to prevent drug-induced skin lesions in BRAF mutation-positive patients treated for melanoma. The studies, presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011, further elucidated...

Image 1 - Chemists Reveal The Force Within You
2011-11-09 11:34:57

[ Watch the Video ] A new method for visualizing mechanical forces on the surface of a cell, reported in Nature Methods, provides the first detailed view of those forces, as they occur in real-time. “Now we´re able to measure something that´s never been measured before: The force that one molecule applies to another molecule across the entire surface of a living cell, and as this cell moves and goes about its normal processes,” says Khalid Salaita, assistant...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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