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Latest Epidermal growth factor receptor Stories

2012-01-19 15:06:30

    The most common form of lung cancer inevitably develops resistance to the targeted drug gefitinib.     This study shows how this resistance develops.     The findings suggest a new strategy for treating non-small cell lung cancer. New research published in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain...

2011-12-12 22:17:53

Scientists have pinpointed a protein that allows brains tumors to invade healthy brain tissue, according to work published this week in the Journal of Experimental Medicine (http://www.jem.org). 40% of a common but deadly type of brain tumor -- called glioblastoma multiforme (GBM) -- have mutations in a gene that encodes a protein called epidermal growth factor receptor (EGFR). These mutations result in hyper-activation of the protein. A team led by Frank Furnari of the Ludwig Institute...

2011-11-14 15:24:49

Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, may have the potential to prevent drug-induced skin lesions in BRAF mutation-positive patients treated for melanoma. The studies, presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011, further elucidated...

Image 1 - Chemists Reveal The Force Within You
2011-11-09 11:34:57

[ Watch the Video ] A new method for visualizing mechanical forces on the surface of a cell, reported in Nature Methods, provides the first detailed view of those forces, as they occur in real-time. “Now we´re able to measure something that´s never been measured before: The force that one molecule applies to another molecule across the entire surface of a living cell, and as this cell moves and goes about its normal processes,” says Khalid Salaita, assistant...

2011-11-07 13:03:26

Findings point to possible personalized brain tumor therapy with Src inhibitors The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports in advance online publication of the journal Nature that PKM2 has important non-metabolic functions in cancer formation. "Our research shows that although PKM2 plays an important role in...

2011-09-26 13:12:21

Effects of a particularly devastating human kidney disease may be blunted by making a certain cellular protein receptor much less receptive, according to new research by scientists from North Carolina State University and a number of French universities and hospitals. The findings take a major step toward suggesting a beneficial treatment for rapidly progressive glomerulonephritis (RPGN), a rare but debilitating kidney disease that causes renal failure and death in humans. In a paper...

2011-09-20 05:54:47

(Ivanhoe Newswire) — Glioblastoma is the most common brain malignancy and one of the most lethal of all cancers, killing most victims within 12-15 months of diagnosis. It is also one of the most chemotherapy-radiation resistant cancers. Researchers found that by blocking brain cancer cells from getting large amounts of cholesterol they could provide a new strategy to battle glioblastoma, according to this study. The study, done in cells lines, mouse models and analysis of tissue from...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.