Latest ERAD Stories
Drug resistance is a serious problem for cancer patients—over time, a therapy that was once providing some benefit simply stops working. Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) recently discovered how cancer cells develop resistance to a drug called MLN4924.
Defective proteins that are not disposed of by the body can cause diseases such as Alzheimer's or Parkinson's.
A study by scientists at the University of California, San Diego and UC Irvine has identified an enzyme called a proteasome phosphatase that appears to regulate removal of damaged proteins from a cell.
The delivery system for an important class of proteins in the cell membrane can be fully replicated with a mere three components.
One bad apple is all it takes to spoil the barrel. And one misfolded protein may be all that's necessary to corrupt other proteins, forming large aggregations linked to several incurable neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's.
Scientists have discovered a small molecule that helps human cells get rid of the misfolded, disfigured proteins implicated in AlzheimerÂ¹s disease and other neurodegenerative ailments.
New research provides crucial insight into the pathogenic mechanisms of Parkinson's disease (PD), a prevalent neurodegenerative disorder.
Findings could one day lead to the development of targeted cancer therapies.
- Withering but not falling off, as a blossom that persists on a twig after flowering.