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Latest Excitotoxicity Stories

2013-10-23 10:19:04

New research by scientists at UC San Francisco shows that one of the brain's fundamental self-protection mechanisms depends on coordinated, finely calibrated teamwork among neurons and non-neural cells knows as glial cells, which until fairly recently were thought to be mere support cells for neurons. The study, which has implications for understanding neurodegenerative diseases, stroke, and other nervous system disorders, adds to a growing body of evidence that glial cells are integral to...

2013-08-08 11:02:05

Study could help yield new drugs for brain disorders Johns Hopkins biophysicists have discovered that full activation of a protein ensemble essential for communication between nerve cells in the brain and spinal cord requires a lot of organized back-and-forth motion of some of the ensemble's segments. Their research, they say, may reveal multiple sites within the protein ensemble that could be used as drug targets to normalize its activity in such neurological disorders as epilepsy,...

2012-06-18 23:20:32

New approach reported in Restorative Neurology and Neuroscience Studies suggest that neurotrophic factors, which play a role in the development and survival of neurons, have significant therapeutic and restorative potential for neurologic diseases such as Huntington's disease. However, clinical applications are limited because these proteins cannot easily cross the blood brain barrier, have a short half-life, and cause serious side effects. Now, a group of scientists has successfully...

2011-11-04 20:55:19

Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have discovered a mechanism by which glioblastoma multiforme (GBM), the most common form of brain cancer, promotes the loss of function or death of neurons, a process known as neurodegeneration. The findings could lead to new therapies that suppress neurodegeneration caused by GBM and, potentially, a variety of other neurodegenerative diseases. The study, recently published in...

2011-10-26 13:12:34

RUB scientists decipher the role of calcium signals Bochum's neurobiologists have found that certain receptors for the neurotransmitter glutamate determine the architecture of nerve cells in the developing brain. Individual receptor variants lead to especially long and branched processes called dendrites, which the cells communicate with. The researchers also showed that the growth-promoting property of the receptors is linked to how much calcium they allow to flow into the cells....

2011-08-17 12:16:52

Findings could be used to develop treatments to protect other nerve cell types responsible for speech and movement Neuroscientists have identified a natural protection mechanism in some of the brain's nerve cells during the onset of stroke. The findings, published today [17 August] in the Journal of Neuroscience, could be used to develop treatments to protect other nerve cell types responsible for speech and movement. Stroke "” the third largest cause of death in the UK "” causes...

2011-05-16 14:34:20

A protective molecule has been identified in the brain which, if used artificially, may prevent brain damage from the likes of stroke, head injury and Alzheimer's. By looking at what happens in the brain after an injury, new research has finally ended speculation over whether a key molecule, 'KCC2' causes brain cell death after an injury or prevents it. The finding, published today (16th May 2011) in The Journal of Physiology now opens the door to the development of artificial forms of the...

2010-09-20 22:20:23

A team of researchers, led by Scott Oakes, at the University of California, San Francisco, has identified a way to prevent symptom onset, weight loss, and paralysis and extend survival in a mouse model of amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease), providing a new avenue of research for the development of therapeutics for ALS and other motor neuron diseases. ALS and other motor neuron diseases are neurological disorders that selectively affect nerve cells that...

2010-01-21 20:34:05

For the first time, research led by Youming Lu, PhD, MD, Professor of Neurology and Neuroscience at LSU Health Sciences Center New Orleans School of Medicine, has identified a novel mechanism that may trigger brain damage during stroke and identified a therapeutic approach to block it. The work, funded by the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS), both of the National Institutes of Health (NIH), as well as the American Heart...

2010-01-21 17:01:08

Biomedical scientists from the University of Central Florida and Louisiana State University have identified a way to block a "cell death signal" that they believe triggers brain damage during strokes. Strokes, also known as cerebral ischemia, are caused by inadequate blood flow to the brain and are the third-leading cause of death in the United States. The team's work focused on a neurotransmitter that typically plays an important role in communication among nerve cells in the brain and...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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