Latest Excitotoxicity Stories
A drug already used to treat symptoms of epilepsy has potential to slow the muscle weakening that comes with amyotrophic lateral sclerosis (ALS), scientists report after completing a Phase II clinical trialâ€”an early, small-scale test to show if the drug works and continues to be safe.
Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with Huntington's disease.
A domain of the NR2B subunit of the NMDA receptor is mapped in exquisite detail.
Glutamate is to the brain like coffee is to our bodies. A cup of Joe in the morning can wake us, but overloading on caffeine causes the stimulant to work against us.
Study shows PIKfyve protects neurons from calcium overload through degradation of calcium channels.
A research article to be published June 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team lead by Dr. Gabriela Beatriz Acosta, observed that the activity of GS was increased in the hippocampus in PH rats.
Statins may protect nerve cells against damage known to occur in the brain of Alzheimer's disease patients, Dutch researchers suggest.
There is a new â€œHUMMRâ€ on the block. It is smaller than its automotive counterpart, but no less powerful.
Scientists have identified a protein in the brain that plays a key role in the function of mitochondria â€“ the part of the cell that supplies energy, supports cellular activity, and potentially wards off threats from disease.
Canadian researchers say they've discovered cells that support neuron survival also play a role in the death of neurons located in the eye. Researchers from the University of Montreal and McGill University said their findings might lead to improved therapies for some neurological disorders, including glaucoma and retinal artery occlusion. The scientists said in many neurodegenerative diseases, a main factor that kills neurons is excessive levels of the neurotransmitter glutamate.
- In medieval musical notation, a sign or neume denoting a shake or trill.