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Latest Experimental autoimmune encephalomyelitis Stories

2011-12-08 07:57:27

(Ivanhoe Newswire) — Save the neurons! A new study suggests laquinimod triggers immune cells within the central nervous system produce and release brain-derived neurotrophic factor, BDNF, contributing to the repair or survival of neurons; therefore limiting brain damage. Laquinimod is an orally available synthetic compound for the treatment of relapsing-remitting multiple sclerosis. "Our data are indicative of a direct and sustained effect of laquinimod on the up-regulation of...

2011-12-06 11:21:42

Results published in the American Journal of Pathology Laquinimod is an orally available synthetic compound that has been successfully evaluated in phase II/III clinical studies for the treatment of relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of laquinimod has not been fully elucidated, but a study published in the January 2012 issue of The American Journal of Pathology suggests that laquinimod triggers immune cells within the central nervous system to produce...

2011-04-25 12:03:16

Researchers uncover role of GM-CSF, an inflammatory cytokine, in T helper cells; blocking it could treat multiple sclerosis Reporting in Nature Immunology, Jefferson neuroscientists have identified a driving force behind autoimmune diseases such as multiple sclerosis (MS), and suggest that blocking this cell-signaling molecule is the first step in developing new treatments to eradicate these diseases. Researchers led by Abdolmohamad Rostami, M.D., Ph.D., Professor and Chairman of the...

2011-02-23 22:22:26

Findings support therapeutic approach for common form of MS In an effort to develop therapeutic remedies for multiple sclerosis, scientists debate two possible interventional approaches - but they're on opposite sides of the spectrum. Researchers at Wayne State University's School of Medicine, however, have reached a definitive conclusion as to which approach is correct, putting an end to a long-disputed issue. Harley Tse, Ph.D., associate professor of immunology and microbiology at WSU's...

2010-10-22 13:44:05

Scientists at Barrow Neurological Institute have recently made discoveries about a type of cell that may limit inflammation in the central nervous system (CNS) "“ a finding that could have important implications in the treatment of brain disorders such as multiple sclerosis. The research, led by Barrow's Fu-Dong Shi, MD, PhD, was published in the August 2010 issue of The Journal of Experimental Medicine, and simultaneously highlighted in Nature. Dr. Shi directs the Neuroimmunology...

2010-09-23 13:23:45

Scientists have uncovered an alternative source for some of the damage associated with multiple sclerosis (MS), an incurable neuroinflammatory disorder. The research, published online by Cell Press on September 23rd in the journal Immunity, reveals a direct interaction between immune cells and neurons that plays a significant role in neuronal injury and may respond to therapeutic intervention. MS is an autoimmune disease in which a person's own immune system attacks their central nervous...

2010-09-23 13:22:10

Researchers in Germany have gained new insight into how the immune system causes damage associated with multiple sclerosis (MS), an incurable neuroinflammatory disorder. Using imaging tools which enable investigation of processes in living organisms, they were able to show a direct interaction between immune cells and neurons which plays a significant role in neuronal injury. However, this direct interaction may respond to therapeutic intervention. The study by Dr. Volker Siffrin and...

2010-05-24 07:29:04

Current research suggests that T helper-type 1 (Th1) cells, previously thought to mediate autoimmunity, may actual inhibit the development of experimental immune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), by suppressing Th17 cells. The related report by Wildbaum et al, "Antigen-specific CD25-Foxp3-IFN-ÃŽ³ high CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17 cells," appears in the June 2010 issue of...

2009-07-23 10:16:00

BELGRADE, SERBIA, July 23 /PRNewswire-FirstCall/ - Hard to Treat Diseases, Inc. (HTDS:PK) http://www.htdsmedical.com reports that researchers in its Slavica BioChem division have advised of some significant findings regarding its research into the use of Ribavirin in the treatment of Multiple sclerosis (MS). The research team has been conducting experiments using Dark Agouti rats. Experimental autoimmune encephalomyelitis (EAE) induced in susceptible strains of animals provides the best...

2009-07-23 08:45:00

Dr. Feng Lin and colleagues at Case Western Reserve University in Cleveland, OH have discovered that the complement inhibitor FUT-175 delays EAE onset. They present these findings in the August 2009 issue of The American Journal of Pathology.Multiple sclerosis (MS) is an autoimmune disease in which the body's immune response attacks the central nervous system (CNS), causing physical and cognitive disability. Complement, molecules involved in clearing infection, may enhance this misguided...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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