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Latest Extracellular signal-regulated kinases Stories

2011-10-10 19:35:28

Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts General Hospital Cancer Center, Boston, has now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers – combine them with inhibitors of the MEK/ERK signaling pathway. In...

2011-04-22 12:55:23

An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology (RCAI) has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells. The finding establishes a role for the extracellular signal-regulated kinase (ERK) signaling pathway in B cell differentiation, a key step toward the development of B cell-targeted drugs for treatment of autoimmune diseases and allergies. As the only cells in the...

2011-04-05 07:00:00

QUEBEC CITY, April 5 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZ) (the "Company") today announced that a poster on its highly selective Erk 1/2 inhibitor anticancer compound, AEZS-131, was presented at the 102(nd) annual meeting of the American Association for Cancer Research currently held at the Orange County Convention Center in Orlando, Florida. Poster #3563 Entitled, "A highly selective Erk 1/2 inhibitor with in-vivo anti tumor potency", Irene Seipelt,...

2009-05-14 13:54:51

Two enzymes called extracellular signal-regulated kinases (ERK1 and ERK2) are critical factors in a pathway that induces ovulation, maturation of the mammalian egg (oocyte) and other activities key to ovarian function and female fertility, said a group of researchers at Baylor College of Medicine (BCM) in a report that appears today in the journal Science."This finding could provide clues to developing new contraceptives and understanding infertility in some women with irregular menstrual...

2008-10-08 09:00:12

Ardea Biosciences has announced positive data from a preclinical study of RDEA119, the company's lead mitogen-activated ERK kinase inhibitor, which showed the product candidate to be a promising investigational therapy for inflammatory diseases. According to the company, oral administration of RDEA119 was shown to significantly reduce damage to colonic tissue and disease activity in dextran sulfate sodium - induced chronic colitic mice. The beneficial effect of RDEA119 exceeded that of...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.