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Last updated on April 17, 2014 at 11:16 EDT

Latest Fanconi anemia Stories

2014-01-24 13:26:27

In laboratory experiments conducted on human cell lines at the Johns Hopkins Kimmel Cancer Center, scientists have shown that people carrying certain mutations in two hereditary cancer genes, BRCA2 and PALB2, may have a higher than usual susceptibility to DNA damage caused by a byproduct of alcohol, called acetaldehyde. The scientists say they suspect that the two genes in their normal forms evolved to protect cells against the damaging effects of acetaldehyde, which can lead to cancer....

2014-01-06 08:22:44

PASADENA, Calif., Jan. 6, 2014 /PRNewswire/ -- Hours away from tonight's highly-anticipated BCS National Championship game in Pasadena, Calif., Florida State University's head football coach, Jimbo Fisher, is already celebrating a tremendous victory off the field. In addition to leading the No. 1 football program to the championship for the first time since 1999, Jimbo and his wife, Candi, made huge strides this season toward raising awareness and funds to fight Fanconi anemia (FA) -...

2013-04-25 20:27:17

The gene could also be involved in breast and ovarian cancer An international research consortium led by the Universitat Autònoma de Barcelona (UAB), the CIBERER and the University of Wurzburg (Germany) has discovered a gene that can cause three totally different diseases, depending on how it is altered. The researchers, using next-generation massive ultrasequencing techniques, have sequenced the over 20,000 genes of a Fanconi anemia patient's genome. By adopting this...

2012-06-17 22:22:04

SEATTLE, June 18, 2012 /PRNewswire/ -- Cell Therapeutics, Inc. ("CTI") (NASDAQ and MTA: CTIC) today announced that the University of Washington ("UW") has begun enrolling patients in a randomized phase II study testing the combination of tosedostat with either cytarabine or decitabine for elderly patients with newly-diagnosed acute myeloid leukemia ("AML") or high-risk myelodysplastic syndrome ("MDS"). Drs. John Pagel and Elihu Estey, from the University of Washington School of Medicine...

2012-06-13 02:26:59

ROCKVILLE, Md., June 13, 2012 /PRNewswire/ -- This week's announcement by ABC News' Robin Roberts that she has been diagnosed with MDS (myelodysplastic syndrome) has drawn national attention to this bone marrow failure disorder. Since 1983, the Aplastic Anemia & MDS International Foundation (www.AAMDS.org) has provided education and support to patients with MDS. MDS is a group of rare disorders affecting the bone marrow. People with MDS have an abnormal number of red and white blood...

2012-05-15 02:28:09

PALO ALTO, Calif., May 15, 2012 /PRNewswire/ -- Telik, Inc. (Nasdaq: TELK) today announced two publications in the Journal of Hematology & Oncology. The first is "Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS)," Raza, A., et al., Journal of Hematology & Oncology 2012, 5:18 doi:10.1186/1756-8722-5-18; 30 April 2012. The publication may be found at...

2012-04-30 14:13:53

Gene Is Involved in Fanconi Anemia — Thale Cress as Model Organism Scientists of KIT and the University of Birmingham have identified relevant new functions of a gene that plays a crucial role in Fanconi anemia, a life-threatening disease. The FANCM gene is known to be important for the stability of the genome. Now, the researchers found that FANCM also plays a key role in the recombination of genetic information during inheritance. For their studies, the scientists used thale cress...

2011-12-15 07:55:26

(Ivanhoe Newswire) — According to a new study, one kind of leukemia sometimes masquerades as another, and researchers are trying to understand why. Leukemia results when normal immune cells accumulate mutations that drive uncontrolled growth. T cell acute lymphoblastic leukemia (T-ALL) derives from immature T cells, whereas acute myeloid leukemia (AML) comes from myeloid cells. Only 50% of adult T-ALL patients can be cured, and a team led by Adolfo Ferrando at Columbia University...

2011-12-13 08:00:00

PALO ALTO, Calif., Dec. 13, 2011 /PRNewswire/ -- Telik, Inc. (Nasdaq: TELK) announced today the results of gene expression analyses conducted during a Phase 2 clinical trial of Telintra in myelodysplastic syndrome (MDS), which may identify patients more likely to respond to Telintra therapy. This work was conducted in collaboration with investigators at Columbia University Medical School and at the Broad Institute of MIT and Harvard University. The presentation was made during the 53rd(...

2011-12-12 23:32:41

Older people with acute myeloid leukemia and normal looking chromosomes in their cancer cells have a higher risk of recurrence if they have mutations in a gene called ASXL1, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James). The study is the first to investigate the influence of these gene mutations on prognosis in patients with...