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Latest Fibrodysplasia ossificans progressiva Stories

2014-01-08 17:39:58

UCSF-led study sheds light on muscle-to-bone transformation Researchers have developed a new way to study bone disorders and bone growth, using stem cells from patients afflicted with a rare, genetic bone disease. The approach, based on Nobel-Prize winning techniques, could illuminate the illness, in which muscles and tendons progressively turn into bone, and addresses the similar destructive process that afflicts a growing number of veterans who have suffered blast injuries — including...

First Proof Of Principle For Treating Rare Bone Disease
2011-11-10 04:53:58

Scientists at Penn´s Perelman School of Medicine Center for Research in FOP and Related Disorders have developed a new genetic approach to specifically block the damaged copy of the gene for a rare bone disease, while leaving the normal copy untouched. Lead author Josef Kaplan, PhD, postdoctoral fellow; and senior authors Eileen M. Shore, PhD, and Frederick S. Kaplan, MD, both from the Department of Orthopaedic Surgery, published this new proof-of-principle approach for treating the...

2011-07-20 17:05:26

Researchers discover brain chemical that causes strange, serious complication For hundreds of thousands of people, injuring a muscle through an accident like falling off a bike or having surgery can result in a strange and serious complication. Their muscles start growing bones. No one understood what caused the abnormal bone growth, so there was no treatment. But now, research from Northwestern University Feinberg School of Medicine and the Perelman School of Medicine at the University of...

2011-04-03 12:00:00

PHILADELPHIA, April 3, 2011 /PRNewswire-USNewswire/ -- Promising new research reveals a potentially highly effective treatment for heterotopic ossification (HO), a painful and often debilitating abnormal buildup of bone tissue. HO comes in two main forms--one that appears in children and is congenital, another that strikes wounded military personnel and surgery patients and is triggered by severe injuries and wounds. An animal study by developmental biologists shows that a drug that...

2010-11-26 11:30:32

(Ivanhoe Newswire) -- As debilitating as disease can be, finding paths that could possibly lead to a cure is quite rewarding. Researchers at Harvard Medical School and the Harvard School of Dental Medicine have found that by mimicking a rare genetic disorder in a dish, they can rewind the internal clock of a mature cell and drive it back into an adult stem-cell stage. This new "stem cell" can then branch out into a variety of differentiated cell types, both in culture and in animal models....

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2009-11-13 08:01:48

Mutation Causing "Leaky" Protein Production Leads to Extra Bone Growth An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. Reporting in the November issue of the...

2009-03-05 12:08:33

A U.S. study has identified the source of immature cells that spur heterotopic ossification -- misplaced bone growth. Researchers at the University of Pennsylvania School of Medicine and the University of Connecticut said they discovered the major repository of bone-forming cells originates in blood vessels deep within skeletal muscle and other connective tissues, and not from muscle stem cells themselves. That finding, said the scientists, shows cells important in the inflammatory response...

2005-11-07 13:31:13

A new research study shows how common a medical misdiagnosis can be and how severely it can exacerbate a disease. Focusing on a rare, genetic and disabling disease known as fibrodysplasia ossificans progressiva, or FOP, researchers designed the study as an examination of the frequency of misdiagnosis and the complications associated with it. Their findings are reported in the November issue of the journal Pediatrics. FOP is a disorder of connective tissue that ultimately results in massive...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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