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Latest Fibronectin Stories

2014-07-02 10:59:23

Cornell University Every living cell's surface has a protein-embedded membrane that's covered in polysaccharide chains – a literal sugar coating. A new study by a Cornell University researcher found this coating is especially thick and pronounced on cancer cells and is a crucial determinant of the cell's survival. Consisting of long, sugar-decorated molecules called glycoproteins, the coating causes physical changes in the cell membrane that make the cell better able to thrive –...

Cancer Cells Break Away
2012-10-11 09:30:45

Connie K. Ho for redOrbit.com — Your Universe Online A new study from the Massachusetts Institute of Technology (MIT) has revealed that cancer cells break away from tumors via adhesion molecules, causing a spread of cancer throughout the body. The findings from the research project were recently published in the journal Nature Communications and offer a glimpse into the possible development of cancer drug targets. “As cancer cells become more metastatic, there can be a...

2012-04-24 23:24:38

Fibronectin plays a major role in wound healing and embryonic development. The protein, which is located in the extracellular matrix of cells, has also been linked to pathological conditions including cancer and fibrosis. During physiological processes, fibronectin fibers are believed to experience mechanical forces that strain the fibers and cause dramatic structural modifications that change their biological activity. While understanding the role of fibronectin strain events in...

2012-02-10 10:31:58

Inflammatory breast cancer (IBC) is the most lethal form of breast cancer. It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New research published in BioMed Central's open access journal Cell Communication and Signaling demonstrates how IBC cells use IL-8, secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression. Fibronectin is a cell-adhesion...

2012-01-23 22:07:58

Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology (www.jcb.org) reveals how a lipid-converting enzyme helps the cells mobilize these integrins. Adhesive integrin proteins continually cycle to and from the cell surface. Invasive cancer cells that carry mutant forms of the tumor suppressor p53 often bias the process, increasing the recycling of a particular integrin that offers a better grip on the fibronectin fibers...

2011-10-24 22:51:44

Infectious films of Staph bacteria around an implanted cardiac device, such as a pacemaker, often force a second surgery to replace the device at a cost of up to $100,000. But not all implanted cardiac devices become infected. Now researchers from Duke University Medical Center and Ohio State University (OSU) have discovered how and why certain strains of Staphylococcus aureus (SA) bacteria, the leading cause of these device infections, have infected thousands of implanted cardiac devices....

2011-03-22 23:06:32

Ninety percent of cancer deaths resulted from metastasis, the spread of cancer to different areas in the body, yet scientific exploration of the possible mechanical factors that promote metastasis has been limited. A Wayne State University researcher, however, is expanding the scientific understanding of what makes malignant tumors spread, and the answer lies within the dense, fibrous matrix that surrounds cancer cells. Karen A. Beningo, Ph.D., assistant professor of biology in WSU's College...

2009-03-19 09:43:40

Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis. The paper, ÃŽ²1 Integrin Cytoplasmic Domain Residues Selectively Modulate Fibronectin Matrix Assembly and Cell Spreading through Talin and Akt-1, will be...

2009-02-25 11:35:28

Researchers have found a way to block the ability of white blood cells to sprint toward the sites of infection when such speed worsens the damage done by sepsis, the often fatal, whole-body bacterial infection, according to a study published today in the journal Blood. The results recommend existing drugs as potential new treatments against sepsis, and suggest improvements in the current treatment that would increase its effect while eliminating a treatment-related risk for internal...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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