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Last updated on April 18, 2014 at 21:21 EDT

Latest Flap endonuclease Stories

2013-06-11 08:32:22

THUWAL, Kingdom of Saudi Arabia, June 11, 2013 /PRNewswire/ -- King Abdullah University of Science and Technology (KAUST) Assistant Professor of Chemistry and Biology and Principal Investigator of the Laboratory of DNA Replication and Recombination, Dr. Samir M. Hamdan, and his team, have published a groundbreaking paper on the mechanism of flap endonuclease 1 (FEN1), in Cell Reports journal. The other authors of the paper, entitled "Sequential and Multistep Substrate...

2011-04-16 00:41:30

A Berkeley Lab-led team deciphers the structure of FEN1, a key player in DNA replication and repair DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role. The structure of human FEN1 has now been solved by an international team of scientists led by the...