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Latest FLT1 Stories

2011-08-15 22:07:30

In a new study published in the August 16th issue of Developmental Cell, researchers at NYU Langone Medical Center identified a molecular mechanism that guarantees that new blood vessels form in the right place and with the proper abundance. "We have known for a long time that blood vessels branch to give rise to new ones and that in some places of our bodies this branching occurs with a reproducible pattern. However, the mechanisms that ensure that new vessels sprout at specific locations...

2011-05-31 12:17:16

Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina "“ a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers. Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel patterning in the retina. Furthermore, in the same study researchers were able to reverse this pathway to accelerate the...

2011-05-29 12:00:00

CINCINNATI, May 29, 2011 /PRNewswire-USNewswire/ -- Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina - a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers. (Logo: http://photos.prnewswire.com/prnh/20110406/MM79025LOGO) Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel...

2008-08-09 03:00:11

By Gustafsdottir, Sigrun M Wennstrom, Stefan; Fredriksson, Simon; Schallmeiner, Edith; Hamilton, Andrew D; Sebti, Said M; Landegren, Ulf BACKGROUND: Improved methods are required to screen drug candidates for their influences on protein interactions. There is also a compelling need for miniaturization of screening assays, with attendant reductions in reagent consumption and assay costs. METHODS: We used sensitive, miniaturized proximity ligation assays (PLAs) to monitor binding of vascular...

2004-11-25 03:00:18

Aim. Imaging with radiolabelled vascular endothelial growth factor (VEGF) has been developed for the localisation and diagnosis of a variety of human solid tumors including gastrointestinal tumors. Methods. In this study we investigated the biodistribution, safety and absorbed dose of iodine-123 radiolabelled VEGF^sub 165^ (^sup 123^I-VEGF^sub 165^) in 9 patients with pancreatic carcinoma. Following intravenous administration of ^sup 123^I-VEGF^sub 165^ (18917 MBq; Results. The highest...