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Last updated on April 18, 2014 at 12:27 EDT

Latest FMR1 Stories

2012-04-25 20:19:20

A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein generated by the gene FMR1, whose dysfunction causes Fragile-X syndrome. The new study appears online April 25 in the journal Neuron. Fragile-X syndrome is the most common cause of inherited intellectual disability. It is also counted among the autism spectrum...

2011-10-31 11:26:45

Penn study in fruit flies has implications for autism, other cognitive impairment syndromes The most common form of heritable cognitive impairment is Fragile X Syndrome, caused by mutation or malfunction of the FMR1 gene. Loss of FMR1 function is also the most common genetic cause of autism. Understanding how this gene works is vital to finding new treatments to help Fragile X patients and others. Researchers from the Perelman School of Medicine at the University of Pennsylvania, and...

2011-06-23 22:58:12

Just like human teenagers, fruit flies that spend a day buzzing around the "fly mall" with their companions need more sleep. That's because the environment makes their brain circuits grow dense new synapses and they need sleep to dial back the energy needs of their stimulated brains, according to a new study by UW- Madison sleep researchers. Researchers saw this increase in the number of synapses -- the junctions between nerve cells where electrical or chemical signals pass to the next cell...

2011-05-18 00:06:47

Advancements over the last 10 years in understanding intellectual disability (ID, formerly mental retardation), have led to the once-unimaginable possibility that ID may be treatable, a review of more than 100 studies on the topic has concluded. It appears in ACS Chemical Neuroscience. Aileen Healy and colleagues explain that people long have viewed intellectual disability as permanent and untreatable, with medical care focusing on relieving some of the symptoms rather than correcting the...

2011-04-13 15:31:53

Individuals with fragile X syndrome, the most common inherited form of intellectual disability, often develop epilepsy, but so far the underlying causes are unknown. Researchers have now discovered a potential mechanism that may contribute to the link between epilepsy and fragile X syndrome. The protein that is missing in fragile X syndrome, FMRP, controls the production of a protein that regulates electrical signals in brain cells, scientists at Emory University School of Medicine have...

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2011-01-12 10:57:22

A researcher at Albert Einstein College of Medicine of Yeshiva University has helped to develop the first genetic blood test for predicting the chances that in vitro fertilization (IVF) will lead to a successful pregnancy. The test, reported in the online medical journal PLoS One, is based on the finding that different subtypes of the FMR1 gene (also known as the fragile X mental retardation gene) in potential mothers are associated with significantly different chances of conceiving with...

2011-01-07 18:45:36

The first drug to treat the underlying disorder instead of the symptoms of Fragile X, the most common cause of inherited intellectual disability, shows some promise according to a new study published in the January issue of Science Translational Medicine. Researchers from Rush University Medical Center helped design the study and are now participating in the larger follow-up clinical trial. The data from the early trial of 30 Fragile X patients, found the drug, called AFQ056, made by Novartis...

2010-12-17 00:00:43

New research from the Center for Human Reproduction identified a first genetic test that can predict pregnancy chances with IVF. One of the investigated FMR1 genotypes was associated with as much as 50% reduction in pregnancy rates, while other genotypes were also associated with distinctly different IVF outcomes. New York, NY (PRWEB) December 16, 2010 Investigators from New York City based Center for Human Reproduction (CHR) report a first genetic test that can predict pregnancy chances...

2010-08-11 13:45:44

Researchers at Emory University School of Medicine have identified a potential new strategy for treating fragile X syndrome, the most common inherited cause of intellectual disability. The researchers have found that a class of drugs called phosphoinositide-3 (PI3) kinase inhibitors can correct defects in the anatomy of neurons seen in a mouse model of fragile X syndrome. In experiments with cultured neurons from the hippocampus, a brain region involved in learning and memory, the drugs could...

2010-07-28 12:18:00

MADISON, N.J., July 28 /PRNewswire/ -- An accurate, faster testing option to identify female carriers and other patients with genetic abnormalities that cause Fragile X Syndrome is now available to physicians in all fifty states with the recent approval in New York. Fragile X is the leading cause of inherited mental retardation and the most common known single gene cause of autism. XSense®, Fragile X with Reflex, from Quest Diagnostics Incorporated (NYSE: DGX), the...