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Latest Focal adhesion Stories

IntegrinMD
2013-03-22 16:03:48

Lawrence Berkeley National Laboratory Your cells are social butterflies. They constantly interact with their surroundings, taking in cues on when to divide and where to anchor themselves, among other critical tasks. This networking is driven in part by proteins called integrin, which reside in a cell´s outer plasma membrane. Their job is to convert mechanical forces from outside the cell into internal chemical signals that tell the cell what to do. That is, when they work properly....

2011-07-25 12:30:19

Findings offer new hope for treatment of TBI in veterans wounded by explosions Bioengineers at Harvard have identified, for the very first time, the mechanism for diffuse axonal injury and explained why cerebral vasospasm is more common in blast-induced brain injuries than in brain injuries typically suffered by civilians. The research addresses two major aspects of traumatic brain injury (TBI), with significant implications for the medical treatment of soldiers wounded by explosions. Two...

2011-07-25 11:52:28

(Ivanhoe Newswire) "“ New findings offer new hope for the treatment of traumatic brain injury (TBI) in veterans wounded by explosions. Researchers have identified for the first time, the mechanism for diffuse axonal injury and explained why cerebral vasospasm is more common in blast-induced brain injuries than in brain injuries typically suffered by civilians. "These results have been a long time coming. So many young men and women are returning from military service with brain...

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2010-08-02 08:01:37

Bioengineers at the University of Pennsylvania have created a system to control the flexibility of the substrate surfaces on which cells are grown without changing the surface properties, providing a technique for more controlled lab experiments on cellular mechanobiology, an important step in the scientific effort to understand how cells sense and respond to mechanical forces in their environment. Researchers created a library of micromolded, hexagonally spaced elastomeric micropost arrays,...

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2010-06-22 07:30:00

Showing movies in 3-D has produced a box-office bonanza in recent months. Could viewing cell behavior in three dimensions lead to important advances in cancer research? A new study led by Johns Hopkins University engineers indicates it may happen. Looking at cells in 3-D, the team members concluded, yields more accurate information that could help develop drugs to prevent cancer's spread. The study, a collaboration with researchers at Washington University in St. Louis, appears in the June...

2010-05-14 08:13:12

University of Pennsylvania bioengineers have demonstrated that the cells that line blood vessels respond to mechanical forces "” the microscopic tugging and pulling on cellular structures "” by reinforcing and growing their connections, thus creating stronger adhesive interactions between neighboring cells. Adherens junctions, the structures that allow cohesion between cells in a tissue, appear to be modulated by endothelial cell-to-cell tugging forces.  Both the size of...

2009-04-13 08:40:01

Study shows FAK coordinates movement of migrating cancer cells Like a climber scaling a rock face, a migrating cancer cell has to keep a tight grip on the surface but also let go at the right moment to move ahead. Chan et al. reveal that the focal adhesion kinase (FAK) coordinates these processes to permit forward movement. The study will be published online April 13 and will appear in the April 20 print issue of the Journal of Cell Biology. Crawling cancer cells send out extensions called...

2009-03-19 09:43:40

Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis. The paper, ÃŽ²1 Integrin Cytoplasmic Domain Residues Selectively Modulate Fibronectin Matrix Assembly and Cell Spreading through Talin and Akt-1, will be...

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2005-09-22 15:00:36

(Philadelphia, PA) - The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness. Now, for the first time, researchers at the University of Pennsylvania School of Medicine have shown that tumor formation is generated by a complex interaction of both mechanical as well as chemical signals, and the resulting tissue stiffening induces molecular signals that...

2005-09-19 15:41:28

Most investigations into cancer have focused on chemical signals, but a new research study provides rare insight into how mechanical force can regulate cellular behavior. The study uncovers a link between tissue tension and tumor formation, suggesting that the stiffness of a tissue can influence molecular signals that promote the malignant behavior of tumor cells. The findings, published in the September issue of Cancer Cell, provide exciting new insight into the mechanisms that link the...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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