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Latest FOXP3 Stories

Oral Immunotherapy Alters DNA Of Those With Peanut Allergies
2014-02-01 06:31:23

Brett Smith for redOrbit.com - Your Universe Online Scientists with Stanford University are finding that healing a peanut allergy with oral immunotherapy alters the DNA of the patient's immune cells. The finding could serve as the basis for a simple blood test to monitor the long-term effectiveness of the allergy therapy. Allergy scientists are currently performing clinical trials of doctor-supervised immunotherapy involving peanut-allergy sufferers taking escalating amounts of peanut...

2013-08-19 13:10:09

In animal studies, CHOP researchers advance new approach to anti-tumor immunotherapy By carefully adjusting the function of crucial immune cells, scientists may have developed a completely new type of cancer immunotherapy—harnessing the body's immune system to attack tumors. To accomplish this, they had to thread a needle in immune function, shrinking tumors without triggering unwanted autoimmune responses. The new research, performed in animals, is not ready for clinical use in...

2012-11-30 16:06:17

Molecule called IKBNS in charge of regulatory immune cell maturation Now, scientists at the Helmholtz Centre for Infection Research (HZI) have looked into the origin of Tregs and uncovered a central role played by the protein IkBNS. Armed with this knowledge, the researchers hope to manipulate Tregs in order to either inhibit or activate the immune system. Biochemist Prof. Ingo Schmitz and his team have now published their findings in the scientific journal Immunity. The immune system...

2011-12-21 13:06:29

It is vital that the body's own immune system does not overreact. If its key players, the helper T cells, get out of control, this can lead to autoimmune diseases or allergies. An immune system overreaction against infectious agents may even directly damage organs and tissues. Immune cells called regulatory T cells ("Tregs") ensure that immune responses take place in a coordinated manner: They downregulate the dividing activity of helper T cells and reduce their production of immune...

2011-11-05 23:15:00

The first study to report the effects vitamin D has on the immune system of people with lupus was reported this week a the American College of Rheumatology Annual Scientific Meeting in Chicago. Chicago, Illinois (PRWEB) November 05, 2011 The first study to report the effects vitamin D has on the immune system of people with lupus was reported this week a the American College of Rheumatology Annual Scientific Meeting in Chicago. Systemic lupus erythematosus, also called SLE or lupus, is a...

2011-09-19 22:24:18

Within the immune system, a subtle balance exists between the cells that destroy alien pathogens and those that preserve the body's own tissues. When the balance gets out of whack, the cells that normally target viruses or bacteria can go astray, attacking innocent cells and causing autoimmune and inflammatory disease. Now, researchers at the University of North Carolina at Chapel Hill have revealed the genetic underpinnings of the cells —called Foxp3-expressing regulatory T cells or...

2011-09-15 20:02:18

It is no easy task to preserve the delicate balance that allows us to maintain a strong immune system that can defend us from harmful pathogens, but that is sensitive enough to correctly identify and spare our own cells. Therefore, it is not surprising that the mechanisms that underlie immune activation and tolerance are not completely understood. Now, a new research study published by Cell Press in the journal Immunity and available online on September 15th provides intriguing insight into...

2011-05-20 07:27:19

(Ivanhoe Newswire)"”Cells found naturally in the body may help prevent the rejection of an organ transplant. Research shows new cell therapy could also eliminate a transplant patient's need for life-long medication and could help their transplant last longer. Currently patients have to take immunosuppressant drugs to prevent a new organ from being rejected after transplant. Unfortunately, these drugs also suppress the immune system leaving the patient more susceptible to tumors and...

2010-05-24 07:29:04

Current research suggests that T helper-type 1 (Th1) cells, previously thought to mediate autoimmunity, may actual inhibit the development of experimental immune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), by suppressing Th17 cells. The related report by Wildbaum et al, "Antigen-specific CD25-Foxp3-IFN-ÃŽ³ high CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17 cells," appears in the June 2010 issue of...

2009-09-22 09:11:56

After more than 50 experiments in mice, medical scientists at Johns Hopkins have mapped out the basic steps taken by a particular set of white blood cells in setting the pace of recovery after serious lung injury. The white blood cells are called regulatory T cells, or Tregs for short, and their best known function is to keep the body's immune system from attacking its own healthy tissues. "Our study results are the critical first leads in finding treatments for a clinical condition that...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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