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Retinoic Acid Gradient Observed For The First Time In A Zebrafish Embryo
2013-04-08 13:31:35

RIKEN In a ground-breaking study, researchers from the RIKEN Brain Science Institute in Japan report a new technique that allows them to visualize the distribution of retinoic acid in a live zebrafish embryo, in real-time. This technique enabled them to observe two concentration gradients going in opposing directions along the head-to-tail axis of the embryo, thus providing long-awaited evidence that retinoic acid is a morphogen. The report, published today in the journal Nature, puts...

2010-12-21 15:36:43

Using fruit flies as a model to study embryo formation, scientists report in Nature Cell Biology that molecular breakdown of a protein called Bicoid is vital to normal head-to-tail patterning of the insect's offspring. Published online by the journal Dec. 19, the study shows how Bicoid is targeted for molecular degradation by a newly identified protein the researchers named Fates-shifted (Fsd). Without the interaction between Bicoid and Fsd, fruit fly embryos are improperly formed and...

2009-09-29 12:36:54

Researchers at the California Institute of Technology (Caltech) have proposed a novel model that differs from a widely held hypothesis about the mechanisms by which developing animals pattern their tissues and structures. Cells in a developing animal require information about their position with respect to other cells so that they can adopt specific patterns of gene expression and function correctly. The most accepted paradigm is that this positional information comes in the form of chemical...