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Latest frontotemporal lobar degeneration Stories

2013-10-30 15:53:44

A new toxic entity associated with genetically inherited forms of dementia and motor neuron disease has been identified by scientists at the UCL Institute of Neurology. The toxin is the result of a genetic mutation that leads to the production of RNA molecules which could be responsible for the diseases. The findings are published in the journal Acta Neuropathologica. Frontotemporal dementia and motor neuron disease are related neurodegenerative diseases that affect approximately 15,000...

2012-12-27 14:21:52

Penn-designed non-invasive MRI screening method is cost-effective, statistically powerful When trying to determine the root cause of a person's dementia, using an MRI can effectively and non-invasively screen patients for Alzheimer's disease or Frontotemporal Lobar Degeneration (FTLD), according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Using an MRI-based algorithm effectively differentiated cases 75 percent of the time, according...

2011-12-01 12:59:48

New research finds a marker used to detect plaque in the brain may help doctors make a more accurate diagnosis between two common types of dementia — Alzheimer's disease and frontotemporal lobar degeneration (FTLD). The study is published in the November 30, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology. "These two types of dementia share similar symptoms, so telling the two apart while a person is living is a real challenge, but...

2011-08-18 06:51:07

(Ivanhoe Newswire) -- Alzheimer's disease and frontotemporal lobar degeneration (FTLD) are two of the most prevalent forms of neurodegenerative disorders. Researchers have analyzed changes in gene expression in the aging and diseased brain, finding new clues to the biology of normal aging and neurodegenerative diseases. In this report, an international team of researchers analyzed and compared changes in gene expression associated with aging and disease in a region of the brain known to be...

2011-08-16 12:24:08

Alzheimer's disease and frontotemporal lobar degeneration (FTLD) are two of the most prevalent forms of neurodegenerative disorders. In a study published online today in Genome Research (www.genome.org), researchers have analyzed changes in gene expression in the aging and diseased brain, finding new clues to the biology of normal aging and neurodegenerative diseases. Recent studies have identified changes in how genes are read, or expressed, in the brain either during aging or with...

2011-01-05 22:59:55

Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) are characterized by protein clumps in brain and spinal-cord cells that include an RNA-binding protein called TDP-43. This protein is the major building block of the lesions formed by these clumps. In a study published in the Journal of Clinical Investigation, a team led by Virginia M.-Y. Lee, PhD, director of Penn's Center for Neurodegenerative Disease Research, describes the first...

2010-11-17 22:13:51

Researchers at the Mayo Clinic campus in Florida have found a clue as to how some people develop a form of dementia that affects the brain areas associated with personality, behavior, and language. In the Nov. 17 online issue of the American Journal of Human Genetics, the scientists write that they discovered a link between two proteins "” progranulin and sortilin "” they say might open new avenues for the treatment of frontotemporal lobar degeneration (FTLD), which occurs in the...

2010-11-17 17:47:20

Frontotemporal lobar degeneration (FTLD) refers to a group of disorders associated with degeneration of the frontal and temporal lobes of the brain. Symptoms include dementia, aphasia, and semantic disorders. Mutation of the gene for PGRN is associated with the most common form of FTLD, which is also characterized by inclusions of TDP-43 protein in the brain. Abnormal accumulation of TDP-43 has also been linked with amyotrophic lateral sclerosis (ALS). While it is clear that a reduction in...


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