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Latest G protein coupled receptors Stories

2012-03-14 13:44:04

How are 100 billion cells created, each with specific duties? The human brain is evidence that nature can achieve this. Researchers at Linköping University in Sweden have now taken a step closer to solving this mystery. "Knowledge about the mechanisms that diversify neurons and keep them diverse is necessary in order to cultivate and replace nerve cells in the future," says Mattias Alenius, Assistant Professor of Neuroscience, who has published his research breakthrough...

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2012-03-14 10:32:54

How are 100 billion cells created, each with specific duties? The human brain is evidence that nature can achieve this. Researchers at Linköping University in Sweden have now taken a step closer to solving this mystery. "Knowledge about the mechanisms that diversify neurons and keep them diverse is necessary in order to cultivate and replace nerve cells in the future," says Mattias Alenius, Assistant Professor of Neuroscience, who has published his research breakthrough in the...

2012-03-08 15:57:15

A new study lead by the Neuroscience Institute of Alicante reveals how manipulating the endocannabinoid system can modulate high levels of impulsivity. This is the main problem in psychiatric illnesses such a schizophrenia, bipolar disorder and substance abuse. Spanish researchers have for the first time proved that the CB2 receptor, which has modulating functions in the nervous system, is involved in regulating impulsive behavior. "Such a result proves the relevance that manipulation...

2012-03-01 07:00:00

SAN DIEGO, March 1, 2012 /PRNewswire/ -- Receptos Inc. today announced that the company is scheduled to present at the Cowen and Company 32nd Annual Health Care Conference at noon EST on Wednesday, March 7, 2012, at the Boston Marriott Copley Place in Boston, Massachusetts. Faheem Hasnain, president and chief executive officer, will provide an overview of the company and an update about its clinical development programs. "This is an exciting time at Receptos as we move forward with plans to...

2012-02-29 13:45:00

SANTA CLARA, Calif., Feb. 29, 2012 /PRNewswire/ -- ConfometRx, a leader in G protein coupled receptor (GPCR) structural characterization and analysis, is pleased to announce that it has expanded its service offerings to include generating iterative crystal structures of new GPCR targets as well as any GPCRs whose structures have been solved using T4-lysozyme (T4-L) fusion technology, and agonist structures using antibodies or G proteins to stabilize active states. The T4-L technology was...

2012-02-29 06:00:00

SEATTLE, Feb. 29, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced that it has identified compounds that functionally interact with each of the following six orphan G protein-coupled receptors (GPCRs): GPR17, GPR153, CCRL2, LGR4, LGR6 and OPN5. Without compounds that functionally interact with orphan GPCRs, developing drugs targeting those receptors is extremely difficult. Omeros has now unlocked 33 of them, representing over 40 percent of the Class A orphan...

2012-02-24 18:00:26

A study from Karolinska Institutet shows that a new drug for Huntington's disease - pridopidine or dopamine stabilizer ACR16 - might operate via previously unknown mechanisms of action. Researchers have found that at very low concentrations, ACR16 binds to the sigma-1 receptor, a protein in the brain important to neuronal function and survival. This new knowledge can be used to develop future treatments for schizophrenia, involuntary Parkinsonian tremors and neurodegenerative diseases....

2012-02-23 06:00:00

SEATTLE, Feb. 23, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that it has identified compounds that interact selectively with each of OGR1, GPR21, GPR50 and GPR52, bringing the total number of orphan G protein-coupled receptors (GPCRs) unlocked by Omeros to 27, representing 35 percent of the Class A orphan GPCRs. There are approximately 120 orphan GPCRs, and Omeros expects to unlock a large percentage of them, focusing first on Class A orphan GPCRs. OGR1, a...

2012-02-16 13:48:00

SAN DIEGO, Feb. 16, 2012 /PRNewswire/ -- Receptos Inc. announced today the publication of key results relating to its expertise in S1P1 biology and structure-based drug discovery for high-value G-protein-coupled receptor (GPCR) targets in Science. The article, entitled "Crystal Structure of a Lipid G Protein-Coupled Receptor," was co-authored by Receptos in collaboration with scientific founders Hugh Rosen, M.D., Ph.D., and Raymond Stevens, Ph.D. Drs. Rosen and Stevens are...

2012-02-16 11:19:22

New evidence that receptors for brain's 'reward' chemical provide protection Brain scans of two strains of mice imbibing significant quantities of alcohol reveal serious shrinkage in some brain regions - but only in mice lacking a particular type of receptor for dopamine, the brain's "reward" chemical. The study, conducted at the U.S. Department of Energy's Brookhaven National Laboratory and published in the May 2012 issue of Alcoholism: Clinical and Experimental Research, now online,...