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Latest G protein coupled receptors Stories

2012-01-26 02:08:43

New research reveals a fascinating and unexpected molecular partnership within the brain neurons that regulate appetite. The study, published by Cell Press in the January 26 issue of the journal Neuron, resolves a paradox regarding a receptor without its hormone and may lead to more specific therapeutic interventions for obesity and disorders of dopamine signaling. Ghrelin is an appetite-stimulating hormone produced by the stomach. Although the ghrelin receptor (GHSR1a) is broadly...

2012-01-19 15:13:40

A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists. A team led by Dana Spence of MSU's Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that...

2012-01-10 06:00:00

SEATTLE, Jan. 10, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that it has identified compounds that interact selectively with each of GPR25, GPR32, GPR80, GPR135 and MAS1, bringing the total number of orphan G protein-coupled receptors (GPCRs) unlocked by Omeros to 23, representing 30 percent of the Class A orphan GPCRs. To date, the number of orphans unlocked by Omeros for drug development equals half of the total number of GPCRs currently targeted by more than 30...

2012-01-05 13:06:49

The problem in biology of how to identify the promoters of olfactory receptor genes (>1000 genes) has remained unsolved due to the difficulty of purifying sufficient material from the olfactory epithelium. Researchers at the RIKEN Omics Science Center, collaborating with scientists from Italy, Norway, the United States, the United Kingdom and Germany, have now solved this problem using nanoCAGE technology, which enables comprehensive analysis of transcription start sites (TSSs) from tiny...

2011-12-13 19:09:56

Angewandte Chemie: 3-D structure and hydrogen bridge pattern explained Banana, mango or apricot - telling these smells apart is no problem for the human nose. How the olfactory organ distinguishes such similar smells has been uncovered by an interdisciplinary team of researchers at the RUB. The scientists were the first to shed light on the dynamics of the three-dimensional structure of the binding site of an olfactory receptor. In so doing, they also found a characteristic pattern of...

2011-12-12 19:00:00

SAN DIEGO, Dec. 12, 2011 /PRNewswire/ -- Receptos Inc. announced today the establishment of a collaboration with Ono Pharmaceutical Co., Ltd. (Osaka, Japan) for the research and development of small molecule modulators of an undisclosed G-protein coupled receptor (GPCR) target. Under the terms of the agreement, Receptos will use its proprietary technology platform to produce high resolution protein crystal structures of the discovery target and drive Ono's structure-based drug...

2011-12-07 22:53:26

The effect of the messenger substance neuropeptide Y depends on the behavior of the mother during infancy Neuropeptide Y (NPY) is the most abundant peptide hormone of the central nervous system. It is involved in various processes including stress management, the development of anxiety behavior and body weight regulation. A collaborative research group including scientists from the Max Planck Institute for Medical Research in Heidelberg has demonstrated using mice that intensive maternal...

2011-12-07 14:27:11

Long the bane of picky eaters everywhere, broccoli´s taste is not just a matter of having a cultured palate; some people can easily taste a bitter compound in the vegetable that others have difficulty detecting. Now a team of Penn researchers has helped uncover the evolutionary history of one of the genes responsible for this trait. Beyond showing the ancient origins of the gene, the researchers discovered something unexpected: something other than taste must have driven its evolution....

2011-12-02 12:50:48

There's an existential crisis that often happens at dinner tables across the country: why won't kids eat their vegetables? Research has found that one reason could be a sensitivity to bitterness, fairly common among children — about 70 percent have it. But a new study led by Jennifer Orlet Fisher, director of the Family Eating Laboratory at Temple's Center for Obesity Research and Education, has found that adding a small amount of dip to a serving of vegetables helped bitter...

2011-11-30 06:00:00

SEATTLE, Nov. 30, 2011 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that with its identification of compounds that interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs) - GPR19, GPR20, GPR31 and GPR141 - it has now unlocked over 20 percent of the 77 Class A orphans. GPCRs represent the premier family of drug targets, with more than 30 percent of currently marketed drugs targeting only 46 GPCRs. There are approximately...