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Latest G protein Stories

2012-06-12 06:23:43

In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified several proteins that help regulate cells´ response to light–and the development of night blindness, a rare disease that abolishes the ability to see in dim light. In the new studies, published recently in the journals Proceedings of the National Academy of Sciences (PNAS) and The Journal of Cell Biology, Scripps Florida scientists were able to show that a family of...

2011-12-28 08:07:10

Half the drugs used today target a single class of proteins — and now scientists have identified an important molecular player critical to the proper workings of those proteins critical to our health. A protein known as Ric-8 plays a vital role, according to new results from a team led by Gregory Tall, Ph.D., assistant professor of Pharmacology and Physiology at the University of Rochester Medical Center. The work was published recently in Science Signaling. What you see, what you...

2011-09-28 19:34:42

Trio of papers describe in unprecedented detail a major molecular target for drugs Three international teams of scientists, led by researchers at the University of California San Diego, University of Michigan and Stanford University, have published a trio of papers describing in unprecedented detail the structure and workings of G protein-coupled receptors (GPCRs), a large family of human proteins that are the target of one-third to one-half of modern drugs. Two of the papers are...

2011-08-04 12:30:00

SAN DIEGO, Aug. 4, 2011 /PRNewswire/ -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD) announced today the publication of research that uncovered a previously unknown role for a class of molecules that could lead to future advances in immunologic medicine. The findings show a definitive link between EBI2, a G-protein-coupled receptor that controls B-cell migration, and some unexpected immunological effects of certain oxysterols. Co-authored by the...

2011-07-26 13:57:09

G protein-coupled receptors (GPCRs) are popular drug targets, accounting for about one-third of approved drugs and many hundreds of drugs currently in development. They act as molecular switches that transduce extracellular signals by activating heterotrimeric G proteins (G proteins) located at the inside of the cell. Changes in shape of these proteins determine essential processes, including whether an eye detects light, a virus invades a cell or a drug slows a racing heart. GPCRs sit in the...

2011-07-20 14:37:08

Researchers influence activity of nerve cells with laser light Unlike conventional methods, with the so-called optogenetics, the researchers are able to target one cell type. "We are now going to use this method to find out exactly what goes wrong in the nerve cells in movement disorders such as ataxias", said Prof. Dr. Stefan Herlitze (RUB Department for Biology and Biotechnology). The researchers report in the Journal of Biological Chemistry. The Bochum team examined a specific signaling...

2011-07-18 14:10:51

Researchers at New York University's Department of Chemistry and NYU Langone Medical Center have developed a compound that blocks signaling from a protein implicated in many types of cancer. The compound is described in the latest issue of the journal Nature Chemical Biology. The researchers examined signaling by receptor tyrosine kinase (RTK). Abnormal RTK signaling is a major underlying cause of various developmental disorders and diseases, including many forms of cancer. RTK signaling...

2011-03-10 23:41:28

Scientists from The Scripps Research Institute have determined a new structure from a medically important superfamily of proteins. The structure should help instruct the design of a new kind of therapeutics for conditions ranging from Parkinson's disease to inflammation. The study, published on March 10, 2011, in Science Express, an advance, online publication of selected research from the journal Science, provides important insights into how this large family of proteins, called G...


Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
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