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Latest G protein Stories

2011-02-07 14:34:55

Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. The results, appearing in the latest issue of the Journal of Cell Biology, promise to open the door to new possibilities for drug development. The work focuses on G protein-coupled receptors (GPCRs), a class of molecules in cell membranes that comprise the largest...

2011-01-12 18:16:42

Discovery means breakthrough for the development of new drugs based on GPCR's Adrenaline, the hormone that prepares our body to fight or flight, acts on a hyperdynamic receptor. This molecule switches so fast between several positions, that it was impossible to image it. Until now. Scientists, including Jan Steyaert of VIB and the Vrije Universiteit Brussel in Belgium, and colleagues from Stanford University in the US, have "frozen the molecule in action" using...

2010-10-22 01:52:02

Scientists at the University of North Carolina at Chapel Hill School of Medicine have reported the exact molecular structure and mechanisms of a major cell signaling pathway that serves a broad range of functions in humans. Up to half of drugs approved by the US Food and Drug Administration directly or indirectly target G protein-coupled receptors. These receptors, which are proteins that live in the outer membranes of cells, take molecular signals from outside the cell and convert them into...

2010-10-08 02:23:30

The findings may lead to new drugs for cancer, immune disorders and AIDS Researchers have determined the structure of a protein that helps guide blood-forming stem cells, or hematopoetic stem cells. The protein is also one of the main receptors used by the human immunodeficiency virus (HIV) to get inside blood cells. The findings are described in the October 7, 2010 issue of the journal Science. The structure offers a detailed view of how the cell surface receptor, called CXCR4, interacts...

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2010-07-30 07:59:25

Researchers at Carnegie Mellon University have developed a new fluorescent biosensor that could aid in the development of an important class of drugs that target a crucial class of proteins called G protein-coupled receptors (GPCRs). "Drugs that target GPCRs make up approximately 30 percent of all pharmaceuticals currently on the market, including some of the most prescribed drugs," said Jonathan Jarvik, the Carnegie Mellon biological sciences professor who led the effort to develop the GPCR...

2010-04-15 07:50:24

Location, location, location determines a protein's role Using a method they developed to watch moment to moment as they move a molecule to precise sites inside live human cells, Johns Hopkins scientists are closer to understanding why and how a protein at one location may signal division and growth, and the same protein at another location, death. Their research, published Feb. 14 in Nature Methods, expands on a more limited method using a chemical tool to move proteins inside of cells to...

2009-07-30 03:58:00

LAUSANNE, Switzerland and MEDFORD, Massachussets, July 30 /PRNewswire/ -- Debiopharm Group (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, and MSM Protein Technologies (MSM), a human antibody drug discovery company with world class expertise in targeting multi-spanning membrane proteins, announce the signature of an exclusive agreement for the development and commercialisation of...

2009-06-09 09:45:00

Uniting Technologies from Multiple Fields, Strengthening the Molecular Bioassays Market MOUNTAIN VIEW, Calif., June 9 /PRNewswire/ -- Based on its recent analysis of the molecular bioassays market, Frost & Sullivan recognizes Cisbio Bioassays with the 2009 Frost & Sullivan North America Technology Innovation of the Year Award. Its innovative, pioneering Tag-lite(TM) technology for cell surface receptor investigation, in particular G protein coupled receptors (GPCRs), brings together...

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2009-04-21 08:10:00

New study in the FASEB Journal shows that our brains make proteins that act directly on the marijuana receptors in our head U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines"”"everybody must get stoned""” is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online in The FASEB Journal, may lead to new marijuana-like drugs...

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2009-01-30 12:36:59

New article in the FASEB Journal reports that scientists have finally captured the elusive signaling device our retinas use to tell us what we see Scientists have known for more than 200 years that vision begins with a series of chemical reactions when light strikes the retina, but the specific chemical processes have largely been a mystery. A team of researchers from the United States and Switzerland, have she new light on this process by "capturing" this chemical communication for future...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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