Latest G-quadruplex Stories

Agreement Includes Phase II Compound SAN DIEGO, March 6, 2013 /PRNewswire/ -- Cylene Pharmaceuticals, Inc. announced today that it has entered into an exclusive, worldwide Option and License Agreement that will allow TetraGene LLC to advance the development of Quarfloxin and Cylene's associated anticancer quadruplex-targeting technologies. Cylene will receive an upfront fee, as well as potential milestone payments and royalties on product sales for the exclusive license. TetraGene...

redOrbit Staff & Wire Reports - Your Universe Online On the 60th anniversary of the publication of the paper describing the double-helix structure of DNA, researchers from Cambridge University reportedly have proven the existence of four-stranded “quadruple helix” DNA structures within the human genome. It was in 1953 that James D. Watson and Francis Crick, also of Cambridge University, published a paper which described the interweaving structure of the double-stranded molecules...

Designers of anti-cancer drugs are aiming their arrows at mysterious chunks of the genetic material DNA that may play a key role in preventing the growth and spread of cancer cells, according to an article in the current issue of Chemical & Engineering News, ACS' weekly newsmagazine.C&EN Deputy Assistant Managing Editor Stu Borman notes that the DNA structures, which scientists term "quadruplexes" because they have four-sided structures, are a genre of folded DNA that may...

The natural world is a shining example when it comes to the self-assembly of molecules. However, it has not disclosed all of its secrets yet. Controlling the shape and structure of self-assembled systems continues to be a stumbling block for scientists. Yet such structures, in which the different molecules cooperate with each other, can have unrivalled characteristics. Self-assembly could provide the way forward for the future mass production of nanomaterials, nanodrugs and...

By Haider, Shozeb Parkinson, Gary N; Neidle, Stephen ABSTRACT Guanine-rich DNA repeat sequences located at the terminal ends of chromosomal DNA can fold in a sequence-dependent manner into G-quadruplex structures, notably the terminal 150-200 nucleotides at the 3' end, which occur as a single-stranded DNA overhang. The crystal structures of quadruplexes with two and four human telomeric repeats show an all-parallel-stranded topology that is readily capable of forming extended stacks of such...