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Latest GABAA receptor Stories

2013-10-07 13:50:24

This press release is in support of a presentation by Dr. Benoit Delatour on Monday Oct. 7 at the 26th ECNP Congress in Barcelona, Spain A selective GABA inverse agonist has restored cognitive function in a mouse model of Down's syndrome (DS) and has the potential to benefit humans, French researchers have revealed. "The drug we used is a specific GABA-A α5 inverse agonist (α5IA) that hypothetically could combat the abnormal neuronal excitation/inhibition balance associated with DS",...

Propofol Breakthrough New Anesthetics
2013-09-23 09:33:59

Brett Smith for redOrbit.com - Your Universe Online New research from an international team of scientists has revealed the specific chemical mechanism behind the anesthetic propofol, the drug widely known for being implicated in the death of music icon Michael Jackson. According to a report published in the journal Nature Chemical Biology, the international team located the specific site on the brain where propofol binds to receptors and sedates patients before surgery. "For many...

New Model Synapse Could Help With Disorders Such As Epilepsy And Anxiety
2012-08-08 09:42:42

A new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction has been developed by a group of scientists led by Gong Chen, an associate professor of biology at Penn State University. The new method involves molecularly engineering a model synapse -- a structure through which a nerve cell sends signals to another cell. This model synapse can precisely control a variety of receptors for the...

2012-06-18 11:01:12

Researchers at Baylor College of Medicine and Texas Children's Hospital have identified commensal bacteria in the human intestine that produce a neurotransmitter that may play a role in preventing or treating inflammatory bowel diseases such as Crohn's disease. "We identified, to our knowledge, the first bifidobacterial strain, Bifidobacterium dentium, that is capable of secreting large amounts of gamma-aminobutyric acid (GABA). This molecule is a major inhibitory neurotransmitter in the...

2012-05-15 22:28:31

A novel mechanism for anxiety behaviors, including a previously unrecognized inhibitory brain signal, may inspire new strategies for treating psychiatric disorders, University of Chicago researchers report. By testing the controversial role of a gene called Glo1 in anxiety, scientists uncovered a new inhibitory factor in the brain: the metabolic by-product methylglyoxal. The system offers a tantalizing new target for drugs designed to treat conditions such as anxiety disorder, epilepsy,...

2012-05-15 22:23:54

Anxiety disorders, ranging from social phobia to post-traumatic stress disorder, are the most common psychiatric diseases in the United States. Research in mice suggests a link between the gene that encodes Glyoxylase 1 (GLO1) and increased anxiety; however, the mechanism underlying this association has remained unclear. The normal role of GLO1 is to degrade cytotoxic byproducts of glycolysis, a function which has no obvious connection to anxiety. Margaret Distler and colleagues at the...

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2011-08-19 10:00:08

Researchers at the Faculty of Pharmaceutical Sciences at the University of Copenhagen have collaborated with the company NeuroSearch to generate new knowledge about an important part of the brain's complex communication system. The discovery could form the basis for future development of better medicines for patients with psychiatric disorders. The results were recently published Journal of Neuroscience. New knowledge challenges established scientific ideas about the function of the...

2011-06-16 13:21:10

Precisely mapped allosteric binding site will facilitate design of drugs with minimal side effects Structural biologists at Cold Spring Harbor Laboratory (CSHL) have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly expressed in brain cells. The newly discovered binding site -- a docking port within the receptor -- is important because it is a potential target for drugs that can modulate...

2011-02-15 19:53:52

    * Alcohol dependence (AD) may develop through alcohol's effects on neural signaling.    * Researchers have found that neuroactive steroids may mediate some of the effects of alcohol on ÃŽ³-aminobutyric acid type A (GABAA) receptors.    * These findings suggest that genetic variations in neuroactive steroid-producing enzymes may be related to risk for AD. One of the ways in which alcohol dependence (AD) may develop is through...

2010-11-12 12:56:25

Multiple presentations at Society for Neuroscience 2010 Allosteric modulation company Addex Pharmaceuticals (SIX:ADXN) announced today that data on a total of nine therapeutic programs will be presented during Society for Neuroscience 2010 (November 13-17, San Diego, USA), highlighting the strength of its allosteric modulation technology platform. The data being presented cover multiple receptor types and therapeutic areas, including Parkinson's disease, schizophrenia, anxiety, Alzheimer's...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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