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Latest Gene duplication Stories

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2010-04-02 12:22:38

New information about early Native Americans' horticultural practices comes not from hieroglyphs or other artifacts, but from a suite of four gene duplicates found in wild and domesticated sunflowers. In an upcoming issue of Current Biology, Indiana University Bloomington biologists present the first concrete evidence for how gene duplications can lead to functional diversity in organisms. In this case, the scientists learned how duplications of a gene called FLOWERING LOCUS T, or FT, could...

2009-11-03 15:45:38

Scientists find new evolutionary mechanism that takes advantage of inefficient selection A painstaking analysis of thousands of genes and the proteins they encode shows that human beings are biologically complex, at least in part, because of the way humans evolved to cope with redundancies arising from duplicate genes. "We have found a specific evolutionary mechanism to account for a portion of the intricate biological complexity of our species," said Ariel Fernandez, professor of...

2009-10-26 15:05:31

Gene copy number variations of the same region, 16p11.2, are already linked to autism An international team of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), has identified a mutation on human chromosome 16 that substantially increases risk for schizophrenia. The mutation in question is what scientists call a copy number variant (CNV). CNVs are areas of the genome where the number of copies of genes differs between individuals. The CNV is located...

2009-10-04 14:51:57

Duke University Medical Center and National Cancer Institute scientists have discovered that a novel genetic alteration "“ a second copy of an entire gene "“ is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system. Inherited differences in gene copy number, known as copy number variation (CNV), have been implicated in some hereditary diseases but none of the previously discovered familial cancer genes has had CNV as...

2009-08-30 12:38:10

Numbers can vary from person to person A newly designed computational method has proven its usefulness in counting copies of duplicated genome sequences and in doing initial assessments of their contents, according to a study to be published Aug. 30 in Nature Genetics. The number of copies of particular DNA segments can differ from one person to the next. The researchers named their method mrFAST, an acronym for micro-read Fast Alignment Search Tool. The study is titled, "Personalized Copy...

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2009-08-13 10:50:00

Extra genomes appear, on average, to offer no benefit or disadvantage to plants, but still play a key role in the origin of new species, say scientists from Indiana University Bloomington and three other institutions in this week's Proceedings of the National Academy of Sciences.Plant biologists have long suspected polyploidy -- the heritable acquisition of extra chromosome sets -- was a gateway to speciation. But the consensus was that polyploidy is a minor force, a mere anomaly that...

2009-08-06 14:11:58

Peering into the DNA of tiny yeast, researchers at the Moores Cancer Center at the University of California, San Diego and the San Diego Branch of the Ludwig Institute for Cancer Research have pinpointed a large number of genes that can prevent a type of genetic rearrangement that may lead to cancer and other diseases.The presence of these genes and their accompanying pathways, many of which are involved in repairing mistakes in DNA replication, may help explain how the body fends off so many...

2009-07-15 13:40:00

Benchmarking copy number variations in healthy people will assist with diagnosis and studies of gene disordersGenetics researchers have unveiled a powerful new resource for scientists and health providers studying human illnesses--a reference standard of deletions and duplications of DNA found in the human genome. Drawn from over 2,000 healthy persons, the study provides one of the deepest and broadest sets of copy number variations (CNVs) available to date, along with a new research tool for...

2009-06-03 13:29:00

ALISO VIEJO, Calif., June 3 /PRNewswire/ -- Ambry Genetics is pleased to announce the launch of whole-genome Chromosomal Microarray Analysis (CMA), offering the Ambry CMA: 105K Oligo Array, which is designed to identify chromosomal abnormalities associated with over 270 genetic disorders. In a partnership with Baylor College of Medicine, Ambry is now able to provide one of the most comprehensive, clinically-validated genetic tests available using array comparative genomic hybridization....

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2009-02-11 16:02:33

A new study by researchers at the University of Washington shows that the evolutionary split between humans and apes may have been spurred by a fast-track genetic change that occurred in a common ancestor. Before the primates' family tree split, the code was fairly stable, except in one fascinating area, researchers said. Sequences of DNA code become duplicated in that area of change and then quickly accelerated, something that could account for the evolutionary break, the research found. It...


Word of the Day
out-herod
  • In the phrase to out-herod Herod, to be more violent than Herod (as represented in the old mystery plays); hence, to exceed in any excess of evil.
Herod refers to 'Herod the Great,' a Roman client king and 'a madman who murdered his own family and a great many rabbis.' According to the OED, the term is 'chiefly with allusion to Shakespeare's use' in Hamlet.
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