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Latest Gene duplication Stories

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2009-01-14 09:47:47

Study of changes in MSX gene family over 600 million years leads to new understanding of disease patterns The work of Forsyth scientist Peter Jezewski, DDS, Ph.D., has revealed that duplication and diversification of protein regions ('modules') within ancient master control genes is key to the understanding of certain birth disorders. Tracing the history of these changes within the proteins coded by the Msx gene family over the past 600 million years has also provided additional evidence for...

2009-01-13 12:23:05

The lack of the important brain protein LIS1 results in lissencephaly, a devastating condition in which the brain appears smooth and does not develop normally. This occurs when a gene called PAFAH1B1 is deleted. If a nearby gene called YWHAE is deleted in combination with PAFAH1B1, a condition called Miller-Dieker syndrome characterized by severe brain abnormalities and other findings. Now a consortium of researchers led by Baylor College of Medicine (www.bmc.edu) in Houston and the Weizmann...

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2008-11-18 09:45:56

A "chip" or array that can quickly detect disorders such as Down syndrome or other diseases associated with chromosomal abnormalities proved an effective tool in prenatal diagnosis in a series of 300 cases at Baylor College of Medicine, said researchers in a report that appears in the current issue of the journal Prenatal Diagnosis. In the report, a team led by Dr. Arthur Beaudet and Dr. Sau Wai Cheung at BCM, described use of array comparative genomic hybridization to analyze samples taken...

2008-10-07 09:00:56

Researchers from France investigating DNA copy number changes associated with genetic disorders have reported the development and validation of a Roche NimbleGen CGH multiplex, microarray-based research method for detecting genomic deletions and duplications at high-resolution. The findings, published in the August 5 issue of the journal Human Mutation (1), identified highly precise, exon-level variants in DNA samples from affected individuals and carriers of a range of human diseases...

2008-07-30 09:00:23

Chromosomal rearrangements leading to genomic disorders are often mediated by low-copy repeat regions of the genome (e.g. segmental duplications). Roche NimbleGen CGH arrays offer expanded probe coverage in these regions. Using this technique, the authors of a recently published paper(1) identified a recurrent reciprocal genomic rearrangement of chromosomal region 17q12 in fetal samples with congenital anomalies that is also associated with pediatric renal disease and epilepsy. The results...

2005-10-26 14:35:31

Cambridge, MA, Wed., Oct. 26, 2005 "“ In several papers published this week in Nature, Nature Genetics, PLoS Biology and Genome Research, Broad researchers and an international set of collaborators announce substantial advances in relating human genetic variation to disease and understanding human evolutionary history. This flurry of high-profile studies are grounded in data described in a significant paper published in the Oct. 27 issue of the journal Nature by an international...

2005-08-22 13:53:38

In a step that advances our ability to discern the ancient evolutionary relationships between different genes and their biological functions, researchers have provided insight into the present-day outcome of a single gene duplication that occurred over a hundred million years ago in an ancestor of modern plants. The work is reported in Current Biology by a team led by Brendan Davies of the University of Leeds, England. Gene duplication--a relatively uncommon event in which a single copy of a...

2005-06-17 10:00:00

Fri., June 17, 2005 "“ Researchers report today that regions of the human genome have been hotspots for acquiring duplicated DNA sequences "“ but only at specific time-points during evolution. It appears that long periods of genomic stasis, at least with regard to the accretion of duplicated DNA fragments, are "punctuated" by relatively brief episodes of duplicative activity. This is the first time that such temporal bias has been documented for DNA duplications, and it challenges...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.