Latest Gene duplication Stories
Study of changes in MSX gene family over 600 million years leads to new understanding of disease patterns
The lack of the important brain protein LIS1 results in lissencephaly, a devastating condition in which the brain appears smooth and does not develop normally.
A "chip" or array that can quickly detect disorders such as Down syndrome or other diseases associated with chromosomal abnormalities proved an effective tool in prenatal diagnosis in a series of 300 cases at Baylor College of Medicine.
Researchers from France investigating DNA copy number changes associated with genetic disorders have reported the development and validation of a Roche NimbleGen CGH multiplex, microarray-based research method for detecting genomic deletions and duplications at high-resolution.
Chromosomal rearrangements leading to genomic disorders are often mediated by low-copy repeat regions of the genome (e.g. segmental duplications). Roche NimbleGen CGH arrays offer expanded probe coverage in these regions.
In several papers published this week in Nature, Nature Genetics, PLoS Biology and Genome Research, Broad researchers and an international set of collaborators announce substantial advances in relating human genetic variation to disease and understanding human evolutionary history.
In a step that advances our ability to discern the ancient evolutionary relationships between different genes and their biological functions, researchers have provided insight into the present-day outcome of a single gene duplication that occurred over a hundred million years ago in an ancestor of modern plants.
Scientists document temporal bias in gene duplication events for a complex region of human chromosome 2.
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