Latest Gene Knockout Stories
Ten years ago, research scientist began trying to understand how a specific feature of a cell called an L-type calcium channel might be related to genetic deafness syndrome.
First mice, then fruit flies, and now knockout nematodes.
LEXINGTON, Ky., Jan.
Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect.
Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., (NASDAQ: SGMO), Sigma-Aldrich Corporation (NASDAQ: SIAL), Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology.
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer.
A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...
- Monstrous in size or character; huge; prodigious; monstrously perverse, savage, cruel, etc.