Latest Gene Knockout Stories

2011-03-11 08:44:19

(Ivanhoe Newswire) -- Ten years ago, research scientist began trying to understand how a specific feature of a cell called an L-type calcium channel might be related to genetic deafness syndrome. This specific feature created a knockout mouse missing both copies of the CACNA1D gene; a gene which makes protein, and allows calcium to flow into other cells. The CACNA1D gene is also important in relaying important instructions from one cell to another. Although the knockout mouse was created...

2010-04-25 13:23:04

First mice, then fruit flies, and now knockout nematodes Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing knockout mice. Kent Golic found a way to cripple fruit fly genes. Now, biologist Erik Jorgensen and colleagues have devised a procedure for knocking out genes in nematode worms. "We developed a method that allows us to walk...

2010-01-20 09:05:00

LEXINGTON, Ky., Jan. 20 /PRNewswire/ -- Transposagen Biopharmaceuticals, Inc., the worldwide leader in the creation of genetically modified laboratory rats, announced today that it has entered into a global marketing and distribution agreement with Taconic, one of the largest animal model and service providers in the world. Under the agreement, Taconic will market and distribute proprietary animal models produced by Transposagen. Transposagen has exclusive worldwide rights to create...

2009-11-13 13:23:06

Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to the PKCI/HINT1 knockout animals, concluding that the deleted gene may have an important role in mood regulation. Elisabeth Barbier and Jia Bei Wang, from the School of Pharmacy at the University of Maryland, USA, carried out the experiments to investigate the role of the gene in regulating mood...

2009-07-23 14:26:44

Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., (NASDAQ: SGMO), Sigma-Aldrich Corporation (NASDAQ: SIAL), Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology.In a paper published in the July 24, 2009 issue of Science, researchers describe the novel application of ZFNs to generate rats with permanent, heritable gene mutations,...

2009-07-01 10:55:00

Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. That's the conclusion of a recent study* in DNA Repair by researchers at the National Institute of Standards and Technology (NIST), Oregon Health and Science University (OHSU) and the New York University School of Medicine (NYUSM).Although all cells need oxygen to survive, the element...

Latest Gene Knockout Reference Libraries

Knockout Mouse
2013-10-02 11:52:01

A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...

More Articles (1 articles) »
Word of the Day
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.