Quantcast

Latest gene regulatory network Stories

2013-07-02 00:04:17

Findings a step toward engineering advanced medical treatments Knowing virtually everything about how the body’s cells make transitions from one state to another – for instance, precisely how particular cells develop into multi-cellular organisms – would be a major jump forward in understanding the basics of what drives biological processes. Such a leap could open doors to far-reaching advances in medical science, bioengineering and...

2013-02-04 14:46:46

By reproducing in the laboratory the complex interactions that cause human genes to turn on inside cells, Duke University bioengineers have created a system they believe can benefit gene therapy research and the burgeoning field of synthetic biology. This new approach should help basic scientists as they tease out the effects of "turning on" or "turning off" many different genes, as well as clinicians seeking to develop new gene-based therapies for human disease. "We know that human...

A Model For Development Built By Biologists
2012-08-31 12:40:24

Caltech biologists create the first predictive computational model of gene networks that control the development of sea-urchin embryos As an animal develops from an embryo, its cells take diverse paths, eventually forming different body parts–muscles, bones, heart. In order for each cell to know what to do during development, it follows a genetic blueprint, which consists of complex webs of interacting genes called gene regulatory networks. Biologists at the California Institute...

2011-09-02 11:40:08

Researchers at the University of Bath have combined genetic data with mathematical modelling to provide insights into cells and how they differentiate. The findings, to be published in open-access journal PLoS Genetics on September 1st, demonstrate the utility of a systems biology approach and could have implications for understanding and treating diseases, including cancers, caused when cells start to function incorrectly. All cells derive from multipotent precursor cells (stem cells)....

2011-06-03 13:11:59

Caltech researchers discover a genomic control system that regulates gut formation in sea-urchin embryos For all animals, development begins with the embryo. It is here that uniform cells divide and diversify, and blueprints are laid for future structures, like skeletal and digestive systems. Although biologists have known for some time that signaling processes"”messages that tell a cell to express certain genes so as to become certain parts of these structures"”exist at this...

2011-05-09 13:09:03

Over the past decades, researchers seeking to understand molecular mechanisms underlying various diseases, notably cancer, have taken advantage of DNA microarrays to interrogate tissues specimen of patients for the expression status of thousands of genes at once. Jointly, such gene expression status of each gene in the genome, measured as the level of their transcripts, constitutes the gene expression profile. Since each of the tens of thousands of genes can be switched on or off, a gene...

2010-03-01 15:44:40

Alcohol use disorders (AUDs) are influenced by multiple genetic, environmental and behavioral factors, which makes it difficult to find individual genetic markers to help identify those at risk of developing AUDs. This study examined how a person's level of response (LR) to alcohol, which is closely linked to the development of AUDs, is related to "gene sets" rather than individual genes. Findings show that glutamate receptor signaling genes that enable brain cells to respond to chemicals,...

2009-11-19 19:17:15

A new statistical technique developed by researchers at the University of Illinois allows scientists to scan a genome for specific gene-regulatory regions without requiring prior knowledge of the relevant transcription factors. The technique has been experimentally validated in both the mouse genome and the fruit fly genome. "Our statistical approach is more widely applicable than other approaches, and is especially useful for investigating gene regulatory networks with relatively little...

2009-09-29 12:36:54

Researchers at the California Institute of Technology (Caltech) have proposed a novel model that differs from a widely held hypothesis about the mechanisms by which developing animals pattern their tissues and structures. Cells in a developing animal require information about their position with respect to other cells so that they can adopt specific patterns of gene expression and function correctly. The most accepted paradigm is that this positional information comes in the form of chemical...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
Related