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Latest Gene silencing Stories

2012-02-02 19:00:39

Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes, and researchers have discovered new mechanisms by which RNA drugs can control gene activity. A comprehensive review article in Nucleic Acid Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc., details these advances. Short strands of nucleic acids, called small RNAs, can be used for targeted gene silencing, making them...

2012-02-02 22:44:50

Using virus vector-mediated RNAi enables scientists to rapidly study the function of insect genes More than 200,000 insects species are herbivores. They depend on plants for food and have adapted their metabolism accordingly in the course of evolution to render plant defenses, such as the toxins plants produce to fend off herbivores, ineffective. The operating instructions of these detoxification processes are coded in different genes. Insects have evolved an enormous diversity of...

2012-01-10 23:35:12

University of Leicester scientists announce a major advance in understanding the regulation of an important cancer target in Nature paper Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding. Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature...

2012-01-05 16:40:50

Discovery reveals new possibility for gene silencing in bacteria and other organisms The knowledge that bacteria possess adaptable immune systems that protect them from individual viruses and other foreign invaders is relatively new to science, and researchers across the globe are working to learn how these systems function and to apply that knowledge in industry and medicine. Now, a team of University of Georgia researchers has discovered how to harness this bacterial immune system to...

2011-11-14 11:32:32

A cell's genome maintains its integrity by organizing some of its regions into a super-compressed form of DNA called heterochromatin. In the comparatively simple organism fission yeast, a cellular phenomenon known as RNA interference (RNAi) plays an essential role in assembling heterochromatin, which keeps the compressed DNA in an inactive or "silent" state. Central to this process is a large protein complex that physically anchors various molecules involved in heterochromatin assembly to the...

2011-09-28 09:41:44

X-chromosome related microRNA may impact immunity and cancer, new study shows As anyone familiar with the phrase 'man-flu' will know women consider themselves to be the more robust side of the species when it comes to health and illness. Now new research, published in BioEssays, seems to support the idea. The research focuses on the role of MicroRNAs encoded on the X chromosome to explain why women have stronger immune systems to men and are less likely to develop cancer. The research,...

2011-08-31 11:00:00

Cenix BioScience GmbH, a leading contract research provider and technology developer specialized in RNAi-, microRNA- and high content-driven pharmacology, and ugichem GmbH, a gene silencing company with an innovative chemistry approach dedicated to expanding the current RNA therapeutics space, today announced that they have entered into a research agreement to advance the latterâs technology platform. Dresden, Germany, and Innsbruck, Austria (PRWEB) August 31, 2011 Cenix...

2011-08-10 18:08:19

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain (IL-2RÃŽ³). The results, which appeared in a recent Proceedings of the National Academy of Sciences, suggest news targets for lymphoma and...

2011-05-12 22:14:40

Discovery, which has implications for cancer, explains why some genes are silenced Japanese and U.S. scientists in the young field of epigenetics Thursday reported a rationale as to how specific genes are silenced and others are not. Because this effect can be reversed, it may be possible to devise therapies for cancer and other diseases using this information. The NOVA U.S. public television program described epigenetics as "The Ghost In Your Genes." It is the study of changes in gene...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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