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Latest Gene silencing Stories

2011-04-13 00:00:27

Overcoming the gene silencing barrier opens doors for gene therapy. Lincoln, NE (PRWEB) April 12, 2011 NTC today announced the award of a Small Business Innovation Research (SBIR) Phase II grant award from the National Institute of General Medical Sciences. The award represents a continuation of a Phase I study, which initially demonstrated the feasibility of overcoming transgene silencing, previously, a major barrier to successful gene therapy. In addition to anti-silencing elements, the...

2010-09-07 17:18:00

- SYL040012 is a new compound arising from Sylentis' research in ophthalmological disorders. - It is indicated for treating ocular hypertension and preventing glaucoma. - SYL040012 is a form of interference RNA (RNAi). - It reduces intraocular pressure by inhibiting the expression of b-adrenergic receptors. MADRID, Sept. 7 /PRNewswire/ -- Sylentis, a biopharmaceutical subsidiary of Grupo Zeltia (MC: ZEL) and a pioneer in the research and development of new drugs based on gene silencing...

2010-06-08 12:42:40

Research finds similarities between pulmonary arterial hypertension and cancer A rare but fatal disease of blood vessels in the lung may be caused in part by aberrant silencing of genes rather than genetic mutation, new research reports. Pulmonary arterial hypertension, a syndrome characterized by gradual blockage of blood vessels in the lungs, has been linked to genetic causes in a small percentage of patients. But University of Chicago researchers have now found that a form of epigenetics...

2010-05-27 07:50:00

In a major cancer-research breakthrough, researchers at the McGill University, Department of Biochemistry have discovered that a small segment of a protein that interacts with RNA can control the normal expression of genes "“ including those that are active in cancer. The research, published online on May 26, 2010 by the prestigious journal Nature, has important immediate applications for laboratory research and is another step toward the kind of individualized cancer therapies...

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2010-05-24 10:54:46

Some cut flowers and potted plants are better than others at fending off the aging process, known as senescence. To help tomorrow's blooms stay fresh longer, Agricultural Research Service (ARS) plant physiologist Cai-Zhong Jiang is investigating the gene-controlled mechanisms of plants' aging. Such probing may eventually reveal how to modify flowers' aging-linked genes, or the proteins that are products of those genes. Jiang is with the ARS Crops Pathology and Genetics Research Unit at Davis,...

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2009-10-13 09:14:18

Berkeley Researchers Get First Look at Gene-Silencing Human RISC-Loading Complex The molecular architecture of a protein complex that helps determine the fate of human cells has been imaged for the first time by researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). Known as a human RISC-loading complex, this structure consists of snippets of ribonucleic acid (RNA) that control whether genetic messages are silenced or expressed. From these new...

2009-02-09 07:45:54

Findings may lead to novel treatments for diseases resistant to current RNAi A team of researchers led by Rutgers' Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over existing RNAi approaches. This may enable the development and discovery of a new class of drugs to treat a wide array of diseases. Critical to the technology is the approach this team took to specifically target RNA biosynthesis. The research findings are reported in the journal...

2008-12-31 10:06:41

While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that "silencing" of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression. In the January 1, 2009, issue of Cancer Research, a journal of the American Association for Cancer Research, they also report finding a strong link between modification...

2008-12-15 09:59:31

Eric Selker's lab reports progress on biochemical communications among proteins involved in gene silencingResearchers in a University of Oregon lab have shed more light on the mechanism that regulates DNA methylation, a fundamental biological process in which a methyl group is attached to DNA, the genetic material in cells of living organisms.DNA methylation is essential for normal growth and development in plants and animals. It has been implicated in long-term memory, and irregularities in...

2008-12-05 09:34:57

The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell.The Histone H3 protein is an important component of chromatin, the packing material wrapping up chromosomal DNA and preventing unwanted transcription of the message encoded in the DNA. Histone H3 can be altered by adding (methylating) or removing (demethylating) methyl groups from the histone protein. When genes are transcribed, parts of...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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