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Latest Gene silencing Stories

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2008-12-03 09:11:32

Discovery an important step in genomics research and quest for better crops Plant researchers from McGill University and the University of California, Berkeley, have announced a major breakthrough in a developmental process called epigenetics. They have demonstrated for the first time the reversal of what is called epigenetic silencing in plants. The findings are important to develop a better understanding of gene regulation in the continuing quest to breed enhanced crops that produce higher...

2008-11-11 09:00:47

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and Cenix BioScience GmbH, a leading RNAi-focused contract research organization, today announced the publication of a new study in the journal PLoS Pathogens demonstrating in vitro and in vivo RNAi-mediated silencing of novel host factors involved in malaria infection. The work resulted from an ongoing malaria research program started as a collaboration announced in 2005 between the group of Dr. Maria Mota at...

2008-10-15 09:00:11

Dicerna Pharmaceuticals, Inc. (www.dicerna.com), a second generation RNA interference company developing novel therapeutics utilizing proprietary Dicer Substrate Technology(TM), announced today the appointment of leading experts to its Scientific Advisory Board (SAB). The newly appointed SAB will serve as a strategic asset to the company as it continues to develop novel RNAi-based therapies that use an earlier step in the gene silencing process, namely the engagement of the enzyme Dicer,...

2008-10-01 09:00:00

Dicerna Pharmaceuticals, Inc. (www.dicerna.com), a second generation RNA interference company developing novel therapeutics utilizing proprietary Dicer Substrate Technology(TM), announced today a paper appearing in the advance online publication of Molecular Therapy which describes the therapeutic potential for Dicer-substrate small interfering RNAs (DsiRNAs) in the treatment of rheumatoid arthritis in a murine model of arthritis. Rheumatoid arthritis is a chronic inflammatory disease...

2008-09-12 03:00:08

By Tuttle, John R Idris, A M; Brown, Judith K; Haigler, Candace H; Robertson, Dominique A silencing vector for cotton (Gossypium hirsutum) was developed from the geminivirus Cotton leaf crumple virus (CLCrV). The CLCrV coat protein gene was replaced by up to 500 bp of DNA homologous to one of two endogenous genes, the magnesium chelatase subunit I gene (ChlI) or the phytoene desaturase gene (PDS). Cotyledons of cotton cultivar 'Deltapine 5415' bombarded with the modified viral vectors...

2008-08-12 09:00:42

Dicerna Pharmaceuticals, Inc. (www.dicerna.com), a second generation RNA interference company developing novel therapeutics utilizing proprietary Dicer Substrate Technology(TM), today announced key studies highlighting the therapeutic potential for Dicer-substrate small interfering RNAs (DsiRNAs). The first study, co-authored by Dicerna co-founder John Rossi, Ph.D., professor in the Division of Molecular Biology and dean, Graduate School of Biological Sciences at City of Hope's Beckman...

2008-07-15 09:01:35

Dicerna Pharmaceuticals, Inc. (www.dicerna.com), an RNA interference company developing novel therapeutics utilizing proprietary Dicer Substrate Technology(TM), today announced a second closing of its Series A financing, receiving a total of $8.4 million in additional venture capital from new investor Abingworth and existing investors Oxford Bioscience Partners and Skyline Ventures. With this additional capital, Dicerna has completed a $21.4 million Series A financing round. Pursuant to this...

2008-06-26 06:01:52

ValiRx plc (AIM:VAL, 'ValiRx'), the cancer therapeutics and diagnostics company, has announced promising in vivo results for its lead molecule VAL 101 which uses its gene silencing technology GeneICE(TM) in preclinical xenograph models of pancreatic cancer. Studies showed that the tumour growth was less than half the size of that seen in the control group. Based on these results, the Company will now initiate further preclinical studies with the aim of progressing VAL 101 toward...

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2008-03-26 15:17:28

A dramatic new study published in the most recent issue of Nature questions some of the mechanisms underlying a new class of drugs based on Nobel Prize-winning work designed to fight diseases ranging from macular degeneration to diabetes. Dr. Jayakrishna Ambati, a University of Kentucky researcher and the paper's senior author, has for years been investigating gene silencing, a 1998 discovery that won a Nobel Prize in Physiology or Medicine in unusually quick fashion in 2006. While the...

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2008-03-18 14:45:00

In large-scale field trials, scientists from North Carolina State University have shown that silencing a specific gene in burley tobacco plants significantly reduces harmful carcinogens in cured tobacco leaves.The finding could lead to tobacco products "“ especially smokeless products "“ with reduced amounts of cancer-causing agents.NC State's Dr. Ralph Dewey, professor of crop science, and Dr. Ramsey Lewis, assistant professor of crop science, teamed with colleagues from the...


Word of the Day
cenobite
  • One of a religious order living in a convent or in community; a monk: opposed to anchoret or hermit (one who lives in solitude).
  • A social bee.
This word comes from the Latin 'coenobium,' convent, which comes from the Greek 'koinobios,' living in community.
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