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Latest Gene therapy Stories

2011-09-01 16:59:02

Biological computer destroys cancer cells Researchers led by ETH professor Yaakov Benenson and MIT professor Ron Weiss have successfully incorporated a diagnostic biological "computer" network in human cells. This network recognizes certain cancer cells using logic combinations of five cancer-specific molecular factors, triggering cancer cells destruction. Yaakov (Kobi) Benenson, Professor of Synthetic Biology at ETH Zurich, has spent a large part of his career developing biological...

2011-09-01 16:44:56

Although several genes have been linked to amyotrophic lateral sclerosis (ALS), it is still unknown how they cause this progressive neurodegenerative disease.In a new study, Columbia University Medical Center (CUMC) researchers have demonstrated that two ALS-associated genes work in tandem to support the long-term survival of motor neurons. The findings were published in the September 1 online edition of the Journal of Clinical Investigation. "Any therapy based on this discovery is...

2011-08-25 00:00:00

AMSTERDAM, The Netherlands, August 25, 2011 /PRNewswire/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, today reported its results for the first half year of 2011. Highlights - Glybera(R): - Data showing Glybera produces significant reduction in risk of pancreatitis in LPLD patients presented at European Atherosclerosis Society Meeting - CHMP does not...

2011-08-24 21:36:19

NIH-Oxford collaboration may offer clues into human brain diseases A new atlas of gene expression in the mouse brain provides insight into how genes work in the outer part of the brain called the cerebral cortex. In humans, the cerebral cortex is the largest part of the brain, and the region responsible for memory, sensory perception and language. Mice and people share 90 percent of their genes so the atlas, which is based on the study of normal mice, lays a foundation for future...

2011-08-16 12:39:19

A clinical trial has shown that a form of gene therapy is safe for treating a deadly form of brain cancer, even when combined with radiation therapy. The phase 1b trial was conducted at the Ohio State University Comprehensive Cancer Center "“ Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC "“ James) and at Methodist at Hospital in Houston, TX. The novel treatment uses an adenovirus vector called AdV-tk. The vector is taken up by cancer cells where...

2011-08-15 22:33:32

In a kind of molecular gymnastics, scientists at the University of North Carolina at Chapel Hill School of Medicine have devised a gene therapy cocktail that has the potential to treat some inherited diseases associated with "misfolded" proteins. Like strings of beads attached end-to-end on a chain, a given sequence of a protein's amino acids usually folds into a characteristic, three-dimensional structure. When "misfolded," a mutant protein's natural biological role may be compromised,...

2011-08-11 13:53:17

Scientists at the National Physical Laboratory (NPL) have mimicked the ways viruses infect human cells and deliver their genetic material. The research hopes to apply the approach to gene therapy "“ a therapeutic strategy to correct defective genes such as those that cause cancer. Gene therapy is still in its infancy, with obvious challenges around targeting damaged cells and creating corrective genes. An equally important challenge, addressed by this research, is finding ways to...

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2011-08-11 10:17:28

In a cancer treatment breakthrough, scientists for the first time have used gene therapy to successfully destroy tumors in patients with advanced chronic lymphocytic leukemia (CLL). Researchers from the University of Pennsylvania's Abramson Cancer Center and Perelman School of Medicine have shown sustained remissions of up to a year among a small group of advanced CLL patients treated with genetically engineered versions of their own T cells. The procedure, which involves removing patients'...

2011-08-10 20:40:05

Genetically engineered spider silk could help overcome a major barrier to the use of gene therapy in everyday medicine, according to a new study that reported development and successful initial laboratory tests of such a material. It appears in ACS' journal Bioconjugate Chemistry. David Kaplan and colleagues note that gene therapy "” the use of beneficial genes to prevent or treat disease "” requires safe and efficient carriers or "vectors." Those carriers are the counterparts to...

2011-07-29 06:00:00

CHICAGO, July 29, 2011 /PRNewswire/ -- Errant Gene Therapeutics, LLC ("EGT"), a pioneering boutique drug development firm specializing in Rare Diseases, announced the transfer of its clinical grade lentiviral vector, TNS 9.55.3, to Memorial Sloan Kettering Cancer Center ("MSKCC"). TNS 9.55.3 developed by EGT pursuant to an exclusive license agreement with Sloan Kettering Institute (SKI), will be used for MSKCC's upcoming beta Thalassemia human clinical trial. The trial protocol provides...