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Latest Gene Stories

Using Supercomputers To Speed Up Genome Analysis
2014-02-20 11:11:12

Lee Rannals for redOrbit.com - Your Universe Online Researchers writing in the journal Bioinformatics say that genome analysis can be radically accelerated. Over the years, the cost of sequencing an entire human genome has dropped, but analyzing three billion base pairs of genetic information from a single genome can take months. A team from the University of Chicago is reporting that one of the world’s fastest supercomputers is able to analyze 240 full genomes in about two days....

2014-02-07 12:48:23

Protein controls editing, expanding the information content of DNA An international team of researchers, led by scientists from the University of California, San Diego School of Medicine and Indiana University, have identified a protein that broadly regulates how genetic information transcribed from DNA to messenger RNA (mRNA) is processed and ultimately translated into the myriad of proteins necessary for life. The findings, published today in the journal Cell Reports, help explain how...

Why Do Women And Men Differ In Height?
2014-02-07 12:41:01

University of Helsinki Researchers from the University of Helsinki analyzed thoroughly the commonly occurring genetic variation in chromosome X, one of the two sex-determining chromosomes, in almost 25,000 Northern European individuals with diverse health-related information available. The aim of the study was to find genetic factors that could explain individual differences in several traits, including BMI, height, blood pressure and lipid levels. In addition, the researchers also...

2014-02-06 08:28:21

PALO ALTO, Calif., Feb. 6, 2014 /PRNewswire/ -- Cellular Research, Inc., today announced that its Molecular Indexing(TM) technology enables the absolute quantification of the starting copy number of an expressed gene, or RNA transcript, in an RNA sequencing (RNA-Seq) library. Data were published in the February 4, 2014 print edition of the Proceedings of the National Academy of Sciences (PNAS), and the article is currently available online. RNA-Seq has become an extremely important...

Precise Gene Modification In Monkeys Paves Way For Valuable Human Disease Models
2014-01-30 15:58:45

Cell Press Monkeys are important for modeling diseases because of their close similarities to humans, but past efforts to precisely modify genes in primates have failed. In a study published by Cell Press January 30th in the journal Cell, researchers achieved precise gene modification in monkeys for the first time using an efficient and reliable approach known as the CRISPR/Cas9 system. The study opens promising new avenues for the development of more effective treatments for a range of...

2014-01-28 12:22:36

Project combines global online design challenge with lab experiments An enthusiastic group of non-experts, working through an online interface and receiving feedback from lab experiments, has produced designs for RNA molecules that are consistently more successful than those generated by the best computerized design algorithms, researchers at Carnegie Mellon University and Stanford University report. Moreover, the researchers gathered some of the best design rules and practices...

2014-01-27 13:30:39

A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe how adjusting the length of the the guide RNA (gRNA) component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases (RGNs) can substantially reduce the occurrence of DNA mutations at sites other than the intended target, a limitation the team had previously...

2014-01-22 12:25:44

Highlights in this week's Molecular Biology and Evolution The baker's yeast Saccharomyces cerevisiae has been associated with human activities for thousands of years, being the primary biological agent in baking, brewing, winemaking and other fermentation processes. It is also one of the most important model organisms in molecular biology and genetics research. For a long time, the history and evolution of this important yeast has been a completely mystery, but recent advances in genome...

Fish DNA For Fingers
2014-01-22 12:35:31

Brett Smith for redOrbit.com - Your Universe Online A new study from a team of Swiss researchers published in the journal PLOS Biology has found that our fish ancestors had the genetic machinery for fingers, but these structures did not develop until the evolution of limbs in amphibians. “The basics of the regulatory mechanism are there in the fish,” said study author Denis Duboule, a geneticist at the University of Geneva and Federal Institute of Technology in Lausanne....

2014-01-16 14:30:04

Application of global sequencing technology reveals how an activator of gene expression stays focused At a glance, DNA is a rather simple sequence of A, G, C, T bases, but once it is packaged by histone proteins into an amalgam called chromatin, a more complex picture emerges. Histones, which come in four subtypes—H2A, H2B, H3, and H4—can either coil DNA into inaccessible silent regions or untwist it to allow gene expression. To further complicate things, small chemical flags, such as...


Latest Gene Reference Libraries

Knockout Mouse
2013-10-02 11:52:01

A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...

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Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'