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Latest Genetic association Stories

2014-05-08 09:51:38

Old data can be mined to find new genetic associations and gene interactions The power of genome-wide association studies (GWAS) to detect genetic influences on human disease can be substantially increased using a statistical testing framework reported in the May issue of the journal GENETICS. Despite the proliferation of GWAS, the associations found so far have largely failed to account for the known effects of genes on complex disease — the problem of "missing heritability."...

2013-08-21 10:32:15

Researchers have identified a new genome-wide significant locus (the place a gene occupies on a chromosome) for infantile hypertrophic pyloric stenosis (IHPS), a serious gastrointestinal condition associated with gastrointestinal obstruction, according to a study in the August 21 issue of JAMA. Characteristics of this locus also suggest the possibility of an inverse relationship between levels of circulating cholesterol in neonates and IHPS risk. "Infantile hypertrophic pyloric stenosis is...

2010-12-31 12:23:59

A large collaborative study has added to the growing list of genetic variants that determine how tall a person will be. The research, published by Cell Press on December 30 in the American Journal of Human Genetics, identifies uncommon and previously unknown variants associated with height and might provide insight into the genetic architecture of other complex traits. Although environmental variables can impact attained adult height, it is clear that height is primarily determined by...

2010-09-29 12:56:00

International collaboration maps height 'hotspots' in the genome BOSTON, Sept. 29 /PRNewswire-USNewswire/ -- An international collaboration of more than 200 institutions, led by researchers at Children's Hospital Boston, the Broad Institute, and a half-dozen other institutions in Europe and North America, has identified hundreds of genetic variants that together account for about 10 percent of the inherited variation of height among people. Known as the GIANT (Genetic Investigation of...

2010-06-25 15:30:47

23andMe, Inc., a leading personal genetics company, announced today that it has published the first data to come out of its novel participant-driven research program. The results, available online in the journal PLoS Genetics, replicate several known genetic associations, validating 23andMe's methodology and ushering in an era of more efficient genetic research. "This paper announces and validates a revolutionary way of conducting scientific research," said Anne Wojcicki, 23andMe President...

2010-06-15 14:29:25

By investigating the association between genetic loci related to Alzheimer's disease and neuroimaging measures related to disease risk, researchers may have uncovered additional evidence that several previously studied genetic variants are associated with the development and progression of Alzheimer's disease and also may have identified new genetic risk factors for further study, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals. "The...

2010-02-17 07:34:24

Creation of a genetic risk score comprised of multiple genetic markers associated with cardiovascular disease (CVD) was not associated with significant improvement in CVD risk prediction in a study that included more than 19,000 women, according to a study in the February 17 issue of JAMA. "Risk prediction is a central part of cardiovascular disease prevention and refining prediction strategies remains important for targeting treatment recommendations. One area of potential improvement has...

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2009-10-12 07:42:37

Genome-wide meta-analysis identifies 22 regions associated with blood cell traits A new genome-wide association study published Oct. 11 in Nature Genetics begins to uncover the basis of genetic variations in eight blood measurements and the impact those variants can have on common human diseases. Blood measurements, including the number and volume of cells in the blood, are routinely used to diagnose a wide range of disorders, including anemia, infection and blood cell cancers. An...

2009-07-01 16:10:06

The single-nucleotide polymorphism (SNP) known as 2q35-rs13387042 is associated with increased risk of estrogen receptor (ER) -positive and -negative breast cancer, according to a study published online July 1 in the Journal of the National Cancer Institute.This study was undertaken to confirm previous research that identified this SNP as a marker of susceptibility to ER"“positive breast cancer.Roger L. Milne, Ph.D., of the Centro Nacional de Investigaciones Oncol³gicas in Madrid,...


Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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