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Latest Genetic epidemiology Stories

2014-05-08 09:51:38

Old data can be mined to find new genetic associations and gene interactions The power of genome-wide association studies (GWAS) to detect genetic influences on human disease can be substantially increased using a statistical testing framework reported in the May issue of the journal GENETICS. Despite the proliferation of GWAS, the associations found so far have largely failed to account for the known effects of genes on complex disease — the problem of "missing heritability."...

2013-08-06 09:13:17

A study by Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD). Data sets from the United Kingdom, Germany, France and the United States were used to perform a combined genome-wide association analysis (GWA). The GWA study of AD included 3,177 patients with AD and 7,277 control patients, and the GWA analysis for PD included 5,333 patients with...

Scientists Hope To Improve Genome-wide Association Studies With Two New Methods
2013-04-26 11:25:54

University of California - San Diego As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of. In a pair of papers published in the April 25, 2013 issue of PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California,...

2013-02-07 15:01:03

Researchers led by biostatistician Andrea Foulkes have applied sophisticated statistical tools to existing large databases to reveal substantial new information about genes that cause such conditions as high cholesterol linked to heart disease Recently, large studies have identified some of the genetic basis for important common diseases such as heart disease and diabetes, but most of the genetic contribution to them remains undiscovered. Now researchers at the University of Massachusetts...

2012-06-16 00:45:57

University of Minnesota School of Public Health researchers have reported two high-signal genetic markers correlated with coronary artery disease (CAD) that should help define genetic fingerprints that can signal an increased risk of developing the disease. The results also offer biological and clinical data supporting future research into the genetic markers and their relationship to CAD, a condition that impacts more than 13 million Americans each year. The research, led by Weihong...

2011-12-05 12:59:43

Singapore and China scientists, headed by Dr Liu Jianjun, Senior Group Leader and Associate Director of Human Genetics at the Genome Institute of Singapore (GIS) and Dr Gu Jieruo, a rheumatologist at the 3rd Affiliated Hospital of the Sun Yat-Sen University, have identified new genes that are associated with the spine disease ankylosing spondylitis (AS). This discovery, reported in the advanced online issue of Nature Genetics on 4 December 2011, brings scientists closer to understanding the...

2011-05-31 13:06:00

Recently the number of genes known to be associated with Alzheimer's disease has increased from four to eight, including the MS4A gene cluster on chromosome 11. New research published in BioMed Central's open access journal Genome Medicine has expanded on this using a genome-wide association study (GWAS) to find a novel location within the MS4A gene cluster which is associated with Alzheimer's disease. Alzheimer's disease is the most common cause of dementia in the developed world. It...

2010-08-09 13:44:22

Finding shows feasibility of carrying out genome-wide association studies in Africa Scientists have identified a genetic variant which increases susceptibility to tuberculosis (TB) in African populations using a technique known as a genome-wide association (GWA) study. This is the first novel disease variant to be identified using this technique in Africans and demonstrates that such studies are viable in African populations, which have a high degree of genetic diversity. Over the past few...

2010-07-22 15:50:29

NIH struggle holds lessons for decision-makers in numerous research arenas Global climate change and other fast-developing scientific fields can take a cue from a prolonged process that eventually led to a workable compromise regarding the release of new data by human genome researchers. A new study by a Washington University in St. Louis School of Law professor in the July 23 issue of the journal "Science" chronicles a 15-year struggle around the competing needs inherent in data-release...

2010-05-27 13:34:46

While genome-wide association (GWA) studies have identified several genetic risk factors for common cancers, their predictive power is limited by their small effect sizes, according to a new study published online May 26 in the Journal of the National Cancer Institute. In the past few years, several GWA studies have reported a large number of gene-disease associations with diverse cancers. But there is ongoing debate on the robustness of these studies and the expensive technology used to...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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