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Latest Genetics of cancer Stories

2011-12-10 02:06:04

Just as people´s bodies and minds can become addicted to substances such as drugs, caffeine, alcohol, their cancers can become addicted to certain genes that ensure their continued growth and dominance. Researchers at Baylor College of Medicine and Harvard Medical School have developed ways to exploit the addictions of cancers to kill them without harming normal tissues. A report on their work appears online today in the journal Science. Many cancers are driven by the...

2011-03-15 16:05:36

Jean-Christophe Marine (VIB, K.U.Leuven) strongly argues against the use of Cop1-inhibitory drugs. The protein Cop1 has "“for a long time - been seen as an attractive drug target for cancer. But Jean-Christophe Marine found out that Cop1 acts as a tumor suppressor, and thus inhibits tumor formation. His new data will have direct implications for the development of cancer drug targets. Tumorigenesis: loss of control Tumors form when control over the cell division is lost; a process that...

2010-11-10 18:14:59

The genes we possess not only determine the color of our eyes and hair and how our bodies grow, they might also influence the changes that occur in tumors when we develop cancer. A study by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC "“ James) suggests that our normal genetic background "“ the genetic variations that we inherit "“ contributes to the kinds of DNA changes...

2009-06-01 12:16:26

A new study uncovers a gene expression signature that reliably identifies cancer cells whose survival is dependent on a common signaling pathway, even when the cells contain multiple other genetic abnormalities. The research, published by Cell Press in the June 2nd issue of the journal Cancer Cell, identifies critical molecular vulnerabilities, thereby revealing promising therapeutic targets for a common and notoriously treatment resistant cancer.Although previous work has identified K-Ras as...

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2009-03-18 14:41:51

The gene Myc is an important factor for the growth of organisms by cell division. It causes the production of a protein which, as a transcription factor, controls the expression of up to 15 % of all human genes. When this gene mutates to an oncogene, the cell proliferates excessively and apoptosis is inhibited. Thereby the gene plays a decisive role in the development of many tumors. The problem is that pharmacological substances do not target Myc as it does not have enzymatic activity of its...

2009-01-06 20:22:48

University of Cincinnati researchers say they've identified a tumor suppressor that may lead to new treatments for lung cancer. Lead author Jorge Moscat said the research focused on specific cellular events that occur in Ras-induced tumor development to better understand the underlying biological mechanisms leading to cancer. These interim steps are critical because they help us determine how best to intervene and stop cancer growth along the way, Moscat, chair of UC's cancer and cell...

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2009-01-05 16:01:53

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biology. Proto-oncogenes are genes that play a role in normal cell growth (turnover of cells and tissue) but, when genetically modified, can cause the out-of-control cell division that leads to cancer....


Word of the Day
maffling
  • To stammer.
  • Present participle of maffle, to stammer.
  • A simpleton.
The word 'maffle' may come from a Dutch word meaning 'to move the jaws' or a French word meaning 'having large cheeks'.