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Last updated on April 18, 2014 at 9:44 EDT

Latest Genome-wide association study Stories

2011-03-09 18:16:34

A team of researchers from the United States and Europe has identified a single genetic mutation in the CUBN gene that is associated with albuminuria both with and without diabetes. Albuminuria is a condition caused by the leaking of the protein albumin into the urine, which is an indication of kidney disease. The research team, known as the CKDGen Consortium, examined data from several genome-wide association studies to identify missense variant (I2984V) in the CUBN gene. The association...

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2011-03-07 12:19:32

Scientists have found 13 new gene variants that increase a person's risk of developing heart disease, which is the world's top killer. The researchers said the discovery of 13 previously unknown gene variations and the confirmation of about 10 more should offer clues about how heart ailments like coronary artery disease develop.  This discovery could lead to new and more effective treatments. The findings also suggest it may be worth mapping someone's profile of genetic variants for...

2011-03-06 12:09:00

REYKJAVIK, Iceland, March 6, 2011 /PRNewswire-FirstCall/ -- Scientists at deCODE genetics and academic colleagues from Iceland, The Netherlands, Denmark, USA and Illumina, Inc., today report the discovery of single-letter variants (SNPs) in the sequence of the human genome associated with high risk of sick sinus syndrome (SSS). The study is published today in the online edition of Nature Genetics. The study reports a genetic variant in the gene MYH6 that is associated with high risk...

2011-03-03 12:56:48

A new study provides fascinating insight into the genetic basis of bipolar disorder, a highly heritable mood disorder characterized by recurrent episodes of mania and depression. The research, published by Cell Press online February 24 in the American Journal of Human Genetics, identifies a previously unrecognized susceptibility factor for bipolar disorder. Genome-wide association studies (GWAS) provide a way to systematically sort through all the DNA of many individuals in order to identify...

2011-02-23 16:38:04

Understanding the genetics of bipolar disorder could lead to new treatments, but identifying specific genetic variations associated with this disorder has been challenging. A new study in Biological Psychiatry implicates a brain protein called Piccolo in the risk for inheriting bipolar disorder. In the orchestra of neuronal proteins, Piccolo is a member of a protein family that includes another protein called Bassoon. Piccolo is located at the endings of nerve cells, where it contributes to...

2011-02-03 20:37:48

A new study takes advantage of genetic similarities between mammals and fruit flies by coupling a complex genetic screening technique in humans with functional validation of the results in flies. The new strategy, published by Cell Press on February 3rd in The American Journal of Human Genetics, has the potential to be an effective approach for unraveling genetically complex human disorders and providing valuable insights into human disease. Genome-wide association studies (GWASs) involve...

2011-01-12 18:30:20

Leading personal genomics company reviews last year's genetic milestones on the journey to understanding the role of genetics in personal health, human development and ancestry 23andMe has released its first annual list of what it felt to be the 10 most interesting and significant genetic findings in 2010, as part of an ongoing journey to understand the role of genetics in personal health and human development. "Our understanding of the human genome is accelerating at a phenomenal rate,"...

2010-12-06 13:17:00

ITHACA, N.Y., Dec. 6, 2010 /PRNewswire-USNewswire/ -- Since sequencing the human genome, genetic researchers have searched intensively but unearthed little evidence to suggest that inherited genes cause common diseases. For such diseases, which include heart disease, stroke, cancers, diabetes, and disorders such as autism, ADHD and dementia, as well as mental illnesses such as schizophrenia and depression, significant genetic causation can now be ruled out with a high degree of confidence....

2010-10-28 22:59:35

A group of researchers at The Scripps Research Institute and the Scripps Translational Science Institute has published a paper that reviews new strategies for identifying collections of rare genetic variations that reveal whether people are predisposed to developing common conditions like diabetes and cancer. In our modern genetic age, the entire DNA sequences, or "genomes," of humans and thousands of other animals, plants, and microbial life forms have been completely decoded and are...

2010-10-18 17:30:40

Genetic variants associated with increased susceptibility to psoriasis are reported in five papers published online this week in Nature Genetics. Psoriasis is a chronic and recurrent skin disease, and one of the most prevalent autoimmune diseases, with a global prevalence of 2-3%. One of the studies was led by the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre (BRC) at Guy's and St Thomas' and King's College London and the Wellcome Trust Centre for...