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Latest Genome-wide association study Stories

2011-07-31 12:35:01

Tokyo, Aug 1, 2011 - (JCN Newswire) - Researchers at the RIKEN Center for Genomic Medicine (CGM), together with colleagues at Kyoto University, Tsukuba University, Harvard University, and other medical institutions have identified three new loci associated with susceptibility to adult asthma in the Japanese population. The findings appear in Nature Genetics and derive from a genome-wide study of 4836 Japanese individuals.Around the world, hundreds of millions of people suffer from bronchial...

2011-07-01 13:00:09

NIH media availability WHAT: A trio of large-scale genome-wide association studies, or GWAS, have identified more than 15 gene variants responsible for the diversity of white blood cell counts among whites, African-Americans, and Japanese. Supported in part by the National Institutes of Health, each study examined the genomes of tens of thousands of people. Combined, the studies offer the first comprehensive analysis into why some people, and some populations, have more or fewer white blood...

2011-07-01 12:52:11

1 step closer to understanding the biology behind disease-associated genetic variants Researchers have developed a new strategy to improve the outcome of genome-wide association (GWA) studies. GWA studies involve rapidly scanning markers across the genomes of many people. By doing this, scientists can look for the association between certain genetic markers or variants within the population, and a particular trait, including disease. However, the challenge is to take these initial association...

2011-05-31 13:06:00

Recently the number of genes known to be associated with Alzheimer's disease has increased from four to eight, including the MS4A gene cluster on chromosome 11. New research published in BioMed Central's open access journal Genome Medicine has expanded on this using a genome-wide association study (GWAS) to find a novel location within the MS4A gene cluster which is associated with Alzheimer's disease. Alzheimer's disease is the most common cause of dementia in the developed world. It...

2011-05-12 00:14:26

Study at the Children's Hospital of Philadelphia yields causes of common variable immunodeficiency A new genomics study, led by the Center for Applied Genomics at The Children's Hospital of Philadelphia, sets the stage for the first predictive diagnostic test in a serious immunodeficiency disease in children. If the disorder, common variable immunodeficiency disease (CVID), can be diagnosed early, children may receive life-saving treatments before the disease can progress. "Currently, there...

2011-03-09 18:16:34

A team of researchers from the United States and Europe has identified a single genetic mutation in the CUBN gene that is associated with albuminuria both with and without diabetes. Albuminuria is a condition caused by the leaking of the protein albumin into the urine, which is an indication of kidney disease. The research team, known as the CKDGen Consortium, examined data from several genome-wide association studies to identify missense variant (I2984V) in the CUBN gene. The association...

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2011-03-07 12:19:32

Scientists have found 13 new gene variants that increase a person's risk of developing heart disease, which is the world's top killer. The researchers said the discovery of 13 previously unknown gene variations and the confirmation of about 10 more should offer clues about how heart ailments like coronary artery disease develop.  This discovery could lead to new and more effective treatments. The findings also suggest it may be worth mapping someone's profile of genetic variants for...

2011-03-06 12:09:00

REYKJAVIK, Iceland, March 6, 2011 /PRNewswire-FirstCall/ -- Scientists at deCODE genetics and academic colleagues from Iceland, The Netherlands, Denmark, USA and Illumina, Inc., today report the discovery of single-letter variants (SNPs) in the sequence of the human genome associated with high risk of sick sinus syndrome (SSS). The study is published today in the online edition of Nature Genetics. The study reports a genetic variant in the gene MYH6 that is associated with high risk...

2011-03-03 12:56:48

A new study provides fascinating insight into the genetic basis of bipolar disorder, a highly heritable mood disorder characterized by recurrent episodes of mania and depression. The research, published by Cell Press online February 24 in the American Journal of Human Genetics, identifies a previously unrecognized susceptibility factor for bipolar disorder. Genome-wide association studies (GWAS) provide a way to systematically sort through all the DNA of many individuals in order to identify...

2011-02-23 16:38:04

Understanding the genetics of bipolar disorder could lead to new treatments, but identifying specific genetic variations associated with this disorder has been challenging. A new study in Biological Psychiatry implicates a brain protein called Piccolo in the risk for inheriting bipolar disorder. In the orchestra of neuronal proteins, Piccolo is a member of a protein family that includes another protein called Bassoon. Piccolo is located at the endings of nerve cells, where it contributes to...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'karpos', fruit.
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