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Last updated on April 23, 2014 at 21:24 EDT

Latest Genome-wide association study Stories

2010-10-06 16:06:01

In an unprecedented international project, researchers have found multiple genetic mutations that play a role in heart attack or coronary artery disease (CAD) risk. The Coronary ARtery DIsease Genome-wide Replication And Meta-Analysis (CARDIoGRAM) "” published in Circulation: Cardiovascular Genetics, an American Heart Association journal "” consists of data from every published whole-genome study on genetic mutations in heart attack or CAD risk. Researchers are also pooling data...

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2010-09-30 06:15:00

Researchers from more than 200 institutions in the U.S. and Europe have identified hundreds of genetic variants that in total account for roughly 10 percent of the inherited variation in human height. The consortium of researchers, named GIANT for Genetic Investigation of ANthropometric Traits, combined data from more than 180,000 individuals, including millions of genetic results from each of 46 separate studies in the U.S., Canada, Europe and Australia. Using this data, they were able to...

2010-09-29 12:56:00

International collaboration maps height 'hotspots' in the genome BOSTON, Sept. 29 /PRNewswire-USNewswire/ -- An international collaboration of more than 200 institutions, led by researchers at Children's Hospital Boston, the Broad Institute, and a half-dozen other institutions in Europe and North America, has identified hundreds of genetic variants that together account for about 10 percent of the inherited variation of height among people. Known as the GIANT (Genetic Investigation of...

2010-09-20 18:49:19

International study locates key genetic variations A consortium of cancer researchers has identified four chromosome locations with genetic changes that are likely to alter a woman's risk of developing ovarian cancer. The findings appear in Nature Genetics in an article authored by a Mayo Clinic researcher. Researchers say that while more needs to be learned about the function of the specific chromosomal regions involved in susceptibility, the discoveries move them a major step closer to...

2010-08-26 14:02:01

University of Oregon's researcher says a genetic variation heightens risk of disease development A 13-member research team led by University of Oregon scientist Dr. Albert O. Edwards has found a gene likely responsible for Fuchs corneal dystrophy, an inheritable genetic disorder and leading cause of corneal transplant operations. Edwards performed a genome-wide analysis comparing patients with and without typical age-related Fuchs, finding an alteration in the transcription-factor-4 gene...

2010-08-09 13:44:22

Finding shows feasibility of carrying out genome-wide association studies in Africa Scientists have identified a genetic variant which increases susceptibility to tuberculosis (TB) in African populations using a technique known as a genome-wide association (GWA) study. This is the first novel disease variant to be identified using this technique in Africans and demonstrates that such studies are viable in African populations, which have a high degree of genetic diversity. Over the past few...

2010-08-05 14:39:41

Scanning the genomes of more than 100,000 people from all over the world, scientists report the largest set of genes discovered underlying high cholesterol and high triglycerides "” the major risk factors for coronary heart disease, the nation's number one killer. Taken together, the gene variants explain between a quarter and a third of the inherited portions of cholesterol and triglyceride measured in the blood. The research, representing scientists from 17 countries, appears in two...

2010-08-05 14:12:01

Discovery may offer new approach to treating coronary artery disease Together with their colleagues from the Global Lipids Genetics Consortium, scientists of Helmholtz Zentrum Mnchen have found 95 gene loci in the human genome, each of which is associated with at least one of the four most important factors of lipoprotein metabolism: total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides. The study focused, along with other aspects, on two key questions: First, are there really...

2010-07-22 15:50:29

NIH struggle holds lessons for decision-makers in numerous research arenas Global climate change and other fast-developing scientific fields can take a cue from a prolonged process that eventually led to a workable compromise regarding the release of new data by human genome researchers. A new study by a Washington University in St. Louis School of Law professor in the July 23 issue of the journal "Science" chronicles a 15-year struggle around the competing needs inherent in data-release...

2010-07-21 22:55:16

Finding may suggest useful drug targets among gene networks Studying a protein already known to play an important role in type 2 diabetes and cancer, genomics researchers have discovered that it may have an even broader role in disease, particularly in other metabolic disorders and heart disease. In finding unsuspected links to other disease-related genes, the scientists may have identified future targets for drug treatments. The paper appeared online July 17 in the British journal...