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Latest Genome-wide association study Stories

2010-08-09 13:44:22

Finding shows feasibility of carrying out genome-wide association studies in Africa Scientists have identified a genetic variant which increases susceptibility to tuberculosis (TB) in African populations using a technique known as a genome-wide association (GWA) study. This is the first novel disease variant to be identified using this technique in Africans and demonstrates that such studies are viable in African populations, which have a high degree of genetic diversity. Over the past few...

2010-08-05 14:39:41

Scanning the genomes of more than 100,000 people from all over the world, scientists report the largest set of genes discovered underlying high cholesterol and high triglycerides "” the major risk factors for coronary heart disease, the nation's number one killer. Taken together, the gene variants explain between a quarter and a third of the inherited portions of cholesterol and triglyceride measured in the blood. The research, representing scientists from 17 countries, appears in two...

2010-08-05 14:12:01

Discovery may offer new approach to treating coronary artery disease Together with their colleagues from the Global Lipids Genetics Consortium, scientists of Helmholtz Zentrum Mnchen have found 95 gene loci in the human genome, each of which is associated with at least one of the four most important factors of lipoprotein metabolism: total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides. The study focused, along with other aspects, on two key questions: First, are there really...

2010-07-22 15:50:29

NIH struggle holds lessons for decision-makers in numerous research arenas Global climate change and other fast-developing scientific fields can take a cue from a prolonged process that eventually led to a workable compromise regarding the release of new data by human genome researchers. A new study by a Washington University in St. Louis School of Law professor in the July 23 issue of the journal "Science" chronicles a 15-year struggle around the competing needs inherent in data-release...

2010-07-21 22:55:16

Finding may suggest useful drug targets among gene networks Studying a protein already known to play an important role in type 2 diabetes and cancer, genomics researchers have discovered that it may have an even broader role in disease, particularly in other metabolic disorders and heart disease. In finding unsuspected links to other disease-related genes, the scientists may have identified future targets for drug treatments. The paper appeared online July 17 in the British journal...

2010-07-13 15:19:48

Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. Although the Greek physician Hippocrates described Behcet's disease (pronounced BET'-chet's), more than 2,000 years ago, the condition existed in relative obscurity until the early 20th century. Named for the Turkish physician who first classified it in 1937, Behcet's disease is found almost...

2010-07-13 14:41:02

Genetic variant detected by genome-wide association found to increase expression of oncogene A genetic variant implicated in several cancers by genome-wide association studies (GWAS) has been found to drive increased expression of a known oncogene in the prostate. The study, published July 13th in Genome Research, showcases a new protocol for studying the activity of cancer-risk variants suggested by GWAS studies. The results also underscore the dramatic consequences of small genetic changes...

2010-06-25 15:30:47

23andMe, Inc., a leading personal genetics company, announced today that it has published the first data to come out of its novel participant-driven research program. The results, available online in the journal PLoS Genetics, replicate several known genetic associations, validating 23andMe's methodology and ushering in an era of more efficient genetic research. "This paper announces and validates a revolutionary way of conducting scientific research," said Anne Wojcicki, 23andMe President...

2010-06-16 23:17:59

Rare gene variants up to nine times more common in affected individuals A multi-institutional research team has found that rare variants in the gene coding an enzyme that controls the activity of a key immune cell occur more frequently in individuals with autoimmune disorders like rheumatoid arthritis and type 1 diabetes. Their report, which will appear in the journal Nature and is receiving early online release, identifies a pathway that could be a therapeutic target and may present a model...

2010-06-15 14:29:25

By investigating the association between genetic loci related to Alzheimer's disease and neuroimaging measures related to disease risk, researchers may have uncovered additional evidence that several previously studied genetic variants are associated with the development and progression of Alzheimer's disease and also may have identified new genetic risk factors for further study, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals. "The...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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